Source:http://linkedlifedata.com/resource/pubmed/id/10738097
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
22
|
| pubmed:dateCreated |
2000-7-17
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| pubmed:abstractText |
A randomized, double-blind, placebo-controlled efficacy trial of one dose of CVD 103-HgR live oral cholera vaccine was performed in Indonesia from 1993 to 1997. 67,508 persons aged 2-41 years ingested vaccine or placebo and were followed for four years, detecting cholera cases using hospital-based surveillance. A nested reactogenicity study (538 vaccinees, 535 controls) revealed no vaccine-attributable side effects. A nested immunogenicity study (N=657) showed vibriocidal seroresponses in 64-70% of vaccinees vs 1-2% of controls. Cholera incidence was lower than expected. 103 cases of Vibrio cholerae O1 El Tor diarrhea were detected, 93 evaluable for vaccine efficacy (43 vaccine, 50 placebo; efficacy=14%). A suggestion of protection was observed among persons with blood group O [P=0.12]. Only seven cases occurred within six months of vaccination, precluding assessment of short-term efficacy. In Jakarta, single-dose CVD 103-HgR did not confer long-term protection. Short-term protection from a single-dose and long-term protection from two doses have yet to be studied.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0264-410X
|
| pubmed:author |
pubmed-author:CryzS JSJ,
pubmed-author:LesmanaM MMM,
pubmed-author:LevineM MMM,
pubmed-author:O'HanleyP PPP,
pubmed-author:PandamS SSS,
pubmed-author:PeetosutanK KKK,
pubmed-author:PunjabiN HNH,
pubmed-author:RichieE EEE,
pubmed-author:SidhartaY YYY,
pubmed-author:SimanjuntakC HCH,
pubmed-author:SukandarM MMM,
pubmed-author:WangsasaputraF FFF,
pubmed-author:WassermanS SSS
|
| pubmed:issnType |
Print
|
| pubmed:day |
8
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2399-410
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:10738097-Administration, Oral,
pubmed-meshheading:10738097-Adolescent,
pubmed-meshheading:10738097-Adult,
pubmed-meshheading:10738097-Child,
pubmed-meshheading:10738097-Child, Preschool,
pubmed-meshheading:10738097-Cholera,
pubmed-meshheading:10738097-Cholera Vaccines,
pubmed-meshheading:10738097-Double-Blind Method,
pubmed-meshheading:10738097-Emigration and Immigration,
pubmed-meshheading:10738097-Female,
pubmed-meshheading:10738097-Humans,
pubmed-meshheading:10738097-Indonesia,
pubmed-meshheading:10738097-Male,
pubmed-meshheading:10738097-Safety,
pubmed-meshheading:10738097-Socioeconomic Factors
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Efficacy trial of single-dose live oral cholera vaccine CVD 103-HgR in North Jakarta, Indonesia, a cholera-endemic area.
|
| pubmed:affiliation |
US Naval Medical Research Unit No. 2, Jakarta, Indonesia.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|