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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2000-5-15
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pubmed:abstractText |
Metropolis Monte Carlo simulation is used to investigate the elasticity of torsionally stressed double-stranded DNA, in which twist and supercoiling are incorporated as a natural result of base-stacking interaction and backbone bending constrained by hydrogen bonds formed between DNA complementary nucleotide bases. Three evident regimes are found in extension versus torsion and force versus extension plots: a low-force regime in which over- and underwound molecules behave similarly under stretching; an intermediate-force regime in which chirality appears for negatively and positively supercoiled DNA and extension of underwound molecule is insensitive to the supercoiling degree of the polymer; and a large-force regime in which plectonemic DNA is fully converted to extended DNA and supercoiled DNA behaves quite like a torsionless molecule. The striking coincidence between theoretic calculations and recent experimental measurement of torsionally stretched DNA (Strick et al., Science. 271:1835, 1996; Biophys. J. 74:2016, 1998) strongly suggests that the interplay between base-stacking interaction and permanent hydrogen-bond constraint takes an important role in understanding the novel properties of elasticity of supercoiled DNA polymer.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10733976-1433295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10733976-1439819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10733976-208457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10733976-2835168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10733976-2926819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10733976-3293798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10733976-5279522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10733976-7919794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10733976-8596951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10733976-8628993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10733976-8628994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10733976-9199777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10733976-9405627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10733976-9545060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10733976-9826669
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0006-3495
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1979-87
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2000
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pubmed:articleTitle |
Monte Carlo implementation of supercoiled double-stranded DNA.
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pubmed:affiliation |
Institute of Theoretical Physics, Academia Sinica, P.O. Box 2735, Beijing 100080, China. zhangy@itp.ac.cn
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pubmed:publicationType |
Journal Article
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