Linked Life Data

10733643

Source:http://linkedlifedata.com/resource/pubmed/id/10733643

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2000-6-1
pubmed:abstractText
GTP-cyclohydrolase I (GTP-CH I) is the initial and rate-limiting enzyme in the synthesis of tetrahydrobiopterin, which regulates melanin biosynthesis. GTP-CH I is therefore a candidate gene for vitiligo. We have carried out DNA sequencing of all six exons and the promoter region of this gene, comprising 1759 base pairs, in 25 nonsyndromic vitiligo patients. However, contrary to an earlier report in which mutations were found in syndromic patients (vitiligo with dopa-responsive dystonia) belonging to two unrelated families, no mutation in the GTP-CH I gene was found.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0307-6938
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
152-3
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Vitiligo is not caused by mutations in GTP-cyclohydrolase I gene.
pubmed:affiliation
Department of Dermatology, Calcutta School of Tropical Medicine, India.
pubmed:publicationType
Journal Article