Source:http://linkedlifedata.com/resource/pubmed/id/10733165
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2000-5-31
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pubmed:abstractText |
Monocytes represent a leukocyte subset that express high levels of CD14 on their surface (CD14-high). These cells play a critical role in the pathogenesis of HIV-1 infection. In the present study, we have identified a monocyte subset expressing an extremely low level of CD14 (CD14-low), and examined their susceptibility to HIV-1 infection. Phenotypic analysis by flow cytometry of these cells revealed a low level of CD4, but the absence of CD3, CD14, CD19, and CD83 surface markers. Both CD14-low and CD14-high cell populations expressed CD13 and CD33 markers on their surface, suggesting these cells to be of myeloid origin. Morphologically, CD14-low cells were indistinguishable from CD14-high cells. CD14-low cells were susceptible to infection with a monocytotropic strain of HIV-1 (HIVADA). However, like CD14-high monocytes, CD14-low cells could not be productively infected with a T cell tropic strain of HIV-1 (H9/HTLV(IIIB)). Similar to CD14-high monocytes, CD14-low cells were capable of inducing antigen-stimulated CD4+ T-cell proliferation. HIV-1 infection substantially reduced their ability to induce antigen-stimulated T-cell proliferation. These data indicate that CD14-low cells belong to the monocyte lineage and may play an important role in the immunopathogenesis of HIV-1 infection.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD13,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD14,
http://linkedlifedata.com/resource/pubmed/chemical/CD83 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins
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pubmed:status |
MEDLINE
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pubmed:issn |
0882-8245
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
19-26
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:10733165-Antigen Presentation,
pubmed-meshheading:10733165-Antigens, CD,
pubmed-meshheading:10733165-Antigens, CD13,
pubmed-meshheading:10733165-Antigens, CD14,
pubmed-meshheading:10733165-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10733165-Flow Cytometry,
pubmed-meshheading:10733165-Fluorescent Antibody Technique,
pubmed-meshheading:10733165-HIV Infections,
pubmed-meshheading:10733165-HIV-1,
pubmed-meshheading:10733165-Humans,
pubmed-meshheading:10733165-Immunoglobulins,
pubmed-meshheading:10733165-Lymphocyte Activation,
pubmed-meshheading:10733165-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:10733165-Membrane Glycoproteins,
pubmed-meshheading:10733165-Microscopy, Electron,
pubmed-meshheading:10733165-Monocytes
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pubmed:year |
2000
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pubmed:articleTitle |
HIV-1 infects and alters immune function of a monocyte subset expressing low CD14 surface phenotype.
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pubmed:affiliation |
Immunopathology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
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pubmed:publicationType |
Journal Article
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