Source:http://linkedlifedata.com/resource/pubmed/id/10730925
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2000-5-2
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| pubmed:abstractText |
We reappraised biochemical hepatitis C activity in hemodialysis patients in comparison with normal controls. A total of 111 hemodialysis patients and 66 healthy volunteer blood donors with hepatitis C virus (HCV) infection were consecutively enrolled. Serum alanine aminotransferase (ALT) levels were normal (< or =45 U/L) in 103 (93%) hemodialysis patients and 34 (52%) donors (p < 0.001). HCV viremic levels were lower in the hemodialysis group (p = 0.044), with no difference in the HCV genotype prevalence. During two-year follow-up, 60 (67%) of 90 hemodialysis patients and 13 (26%) of 50 donors showed persistently normal ALT levels (p < 0.001). For hemodialysis patients, however, the upper normal limit of ALT activity was reset at 25 U/L corresponding to the mean + 2 x SD for the normalized ALT distribution in 400 control patients. The adjusted ALT levels were initially normal in 73 (66%) hemodialysis patients and persistently normal in 19 (21%). Thus, ALT levels were the same for the two groups. GB virus C (GBV-C)/hepatitis G virus (HGV) coinfection found only in the hemodialysis group (10/111) had no influence on the disease. A relationship was noted between low disease activity and female gender in both groups. These findings indicate that biochemical hepatitis C activity in hemodialysis patients is similar to that in normal controls and should be monitored based on adjusted ALT levels.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0192-0790
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
30
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
187-94
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10730925-Alanine Transaminase,
pubmed-meshheading:10730925-Case-Control Studies,
pubmed-meshheading:10730925-Clinical Enzyme Tests,
pubmed-meshheading:10730925-Female,
pubmed-meshheading:10730925-Flaviviridae,
pubmed-meshheading:10730925-Follow-Up Studies,
pubmed-meshheading:10730925-Hepatitis, Viral, Human,
pubmed-meshheading:10730925-Hepatitis C,
pubmed-meshheading:10730925-Humans,
pubmed-meshheading:10730925-Kidney Failure, Chronic,
pubmed-meshheading:10730925-Male,
pubmed-meshheading:10730925-Middle Aged,
pubmed-meshheading:10730925-Prevalence,
pubmed-meshheading:10730925-Reference Values,
pubmed-meshheading:10730925-Renal Dialysis,
pubmed-meshheading:10730925-Time Factors
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| pubmed:year |
2000
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| pubmed:articleTitle |
Reappraisal of biochemical hepatitis C activity in hemodialysis patients.
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| pubmed:affiliation |
Department of Gastroenterology, Osaka National Hospital, Japan.
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| pubmed:publicationType |
Journal Article
|