Linked Life Data

10729385

Source:http://linkedlifedata.com/resource/pubmed/id/10729385

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2000-5-16
pubmed:abstractText
The mechanism of diabetic macroangiopathy was studied from the view point of phenotypic change of arterial smooth muscle cells (SMC). Otsuka Long-Evans Tokushima fatty (OLETF) rat, an animal model of non-insulin dependent diabetes mellitus (NIDDM), develops spontaneous persistent hyperglycemia after the age of 18 weeks. Medial SMC in OLETF rats expressed more platelet-derived growth factor (PDGF) beta-receptor and fibronectin at the protein level than those from control, Long-Evans Tokushima Otsuka (LETO) rats, not only after but also before the onset of diabetes mellitus. Cultured SMC from OLETF rats more strongly responded specifically to the mitogenic stimuli of PDGF-AB and PDGF-BB and also expressed PDGF beta-receptor more intensely compared with those from LETO rats. PDGF is known to be the main contributor to the intimal thickening induced by balloon catheter injury, which is one of several forms of arterial injuries. Intimal thickening of carotid arteries in OLETF rats after balloon catheter injury increased compared with that in LETO rats before the onset of diabetes mellitus. In in vitro culture system, fibronectin synthesis was stimulated by transforming growth factor-beta1(TGF-beta1) in SMC from OLETF rats, but not in those from LETO rats, suggesting that SMC from OLETF rats respond to TGF-beta1. These results indicate that overexpression of PDGF beta-receptor and fibronectin in medial SMC plays an important role in the accelerated intimal thickening before the onset of diabetes mellitus in OLETF rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0021-9150
pubmed:author
pubmed:issnType
Print
pubmed:volume
149
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
351-8
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:10729385-Animals, pubmed-meshheading:10729385-Aorta, Thoracic, pubmed-meshheading:10729385-Cell Division, pubmed-meshheading:10729385-Cells, Cultured, pubmed-meshheading:10729385-DNA, pubmed-meshheading:10729385-Diabetes Mellitus, Type 2, pubmed-meshheading:10729385-Disease Models, Animal, pubmed-meshheading:10729385-Fibronectins, pubmed-meshheading:10729385-Male, pubmed-meshheading:10729385-Muscle, Smooth, Vascular, pubmed-meshheading:10729385-Platelet-Derived Growth Factor, pubmed-meshheading:10729385-Rats, pubmed-meshheading:10729385-Rats, Inbred OLETF, pubmed-meshheading:10729385-Receptor, Platelet-Derived Growth Factor beta, pubmed-meshheading:10729385-Reference Values, pubmed-meshheading:10729385-Sensitivity and Specificity, pubmed-meshheading:10729385-Tunica Intima
pubmed:year
2000
pubmed:articleTitle
Increased atherogenesis in Otsuka Long-Evans Tokushima fatty rats before the onset of diabetes mellitus: association with overexpression of PDGF beta-receptors in aortic smooth muscle cells.
pubmed:affiliation
Second Department of Internal Medicine, School of Medicine, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, Japan.
pubmed:publicationType
Journal Article, Comparative Study