Linked Life Data

10729357

Source:http://linkedlifedata.com/resource/pubmed/id/10729357

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2000-6-2
pubmed:abstractText
Although conditioned fear has been shown to involve mechanisms of synaptic plasticity in the amygdala, the association with afferent input systems is not yet clear. Here we report on homosynaptic long-term depression (LTD) of excitatory responses after stimulation of putative thalamic input fibers, but not of cortical inputs, to the rat lateral amygdala in vitro. LTD is induced by theta frequency stimulation and involves postsynaptic calcium-dependent mechanisms and group II metabotropic glutamate receptors. These input-specific changes in synaptic strength represent potential cellular sources, which regulate the balance between sensory thalamic and cortical input signals to the amygdala. This regulation would function to reduce the influence of relatively undiscriminated stimulus information carried by thalamic afferents in favor of discriminated sensory information mediated by the cortex during fear responses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
RC68
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Input-specific long-term depression in the lateral amygdala evoked by theta frequency stimulation.
pubmed:affiliation
Otto-von-Guericke-Universit¿t, Institut f¿r Physiologie, D-39120 Magdeburg, Germany.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't