Linked Life Data

10727714

Source:http://linkedlifedata.com/resource/pubmed/id/10727714

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2000-5-25
pubmed:abstractText
8-OH-DPAT [8-hydroxy-2-(di-N-propylamino)tetralin], a 5-HT(1A) receptor agonist, and S 15535 (4-benzodioxan-5-yl)1-(indan-2-yl)piperazine, a partial agonist at 5-HT(1A) receptors, were administered into the dorsal raphe nucleus and dorsal hippocampus and their behavioral effects were assessed in a modified Geller-Seifter conflict model. Injected into the dorsal raphe nucleus 8-OH-DPAT, 1 microg but not 0.04 or 0.2 microg 0.5 microl(-1), and S 15535, 2.5 microg but not 0.1 or 0.5 microg 0.5 microl(-1), significantly increased punished responding with no effect on rates of unpunished or time-out responding. WAY 100635, a selective 5-HT(1A) receptor antagonist, injected subcutaneously at 0. 3 mg kg(-1) 30 min before 1 microg 8-OH-DPAT or 2.5 microg S 15535 in the dorsal raphe, completely antagonized their effects on punished responding. At doses ranging from 1 to 10 microg microl(-1) injected into the CA1 region of the dorsal hippocampus neither 8-OH-DPAT nor S 15535 modified punished responding or the rates of time-out. At the highest doses, 8-OH-DPAT significantly reduced unpunished responding whereas S 15535 had the opposite effect. The results suggest that stimulation of 5-HT(1A) receptors in the dorsal raphe nucleus has anxiolytic-like effects whereas stimulation of postsynaptic receptors in the dorsal hippocampus has no anxiolytic or anxiogenic effects, at least judging from changes in rates of punished responding. These results are compatible with the hypothesis that 5-HT(1A) receptor agonists and partial agonists attenuate anxiety by reducing serotonergic transmission in brain areas innervated by the dorsal raphe nucleus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0028-3908
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1037-43
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:10727714-8-Hydroxy-2-(di-n-propylamino)tetralin, pubmed-meshheading:10727714-Animals, pubmed-meshheading:10727714-Anxiety, pubmed-meshheading:10727714-Conditioning, Operant, pubmed-meshheading:10727714-Conflict (Psychology), pubmed-meshheading:10727714-Hippocampus, pubmed-meshheading:10727714-Male, pubmed-meshheading:10727714-Piperazines, pubmed-meshheading:10727714-Punishment, pubmed-meshheading:10727714-Pyridines, pubmed-meshheading:10727714-Raphe Nuclei, pubmed-meshheading:10727714-Rats, pubmed-meshheading:10727714-Rats, Sprague-Dawley, pubmed-meshheading:10727714-Receptors, Serotonin, pubmed-meshheading:10727714-Receptors, Serotonin, 5-HT1, pubmed-meshheading:10727714-Serotonin Antagonists, pubmed-meshheading:10727714-Serotonin Receptor Agonists, pubmed-meshheading:10727714-Stereotaxic Techniques
pubmed:year
2000
pubmed:articleTitle
Roles of 5-HT(1A) receptors in the dorsal raphe and dorsal hippocampus in anxiety assessed by the behavioral effects of 8-OH-DPAT and S 15535 in a modified Geller-Seifter conflict model.
pubmed:affiliation
Istituto di Ricerche Farmacologiche "Mario Negri", Via Eritrea 62, 20157, Milan, Italy.
pubmed:publicationType
Journal Article