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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2000-4-21
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pubmed:abstractText |
We examined enhancement of synaptic transmission by neurotrophins at the presynaptic level. In a synaptosomal preparation, brain-derived neurotrophic factor (BDNF) increased mitogen-activated protein (MAP) kinase-dependent synapsin I phosphorylation and acutely facilitated evoked glutamate release. PD98059, used to inhibit MAP kinase activity, markedly decreased synapsin I phosphorylation and concomitantly reduced neurotransmitter release. The stimulation of glutamate release by BDNF was strongly attenuated in mice lacking synapsin I and/or synapsin II. These results indicate a causal link of synapsin phosphorylation via BDNF, TrkB receptors and MAP kinase with downstream facilitation of neurotransmitter release.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1097-6256
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
323-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10725920-Animals,
pubmed-meshheading:10725920-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:10725920-Enzyme Inhibitors,
pubmed-meshheading:10725920-Flavonoids,
pubmed-meshheading:10725920-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:10725920-Glutamic Acid,
pubmed-meshheading:10725920-MAP Kinase Signaling System,
pubmed-meshheading:10725920-Male,
pubmed-meshheading:10725920-Mice,
pubmed-meshheading:10725920-Mice, Inbred C57BL,
pubmed-meshheading:10725920-Mice, Mutant Strains,
pubmed-meshheading:10725920-Neurons,
pubmed-meshheading:10725920-Phosphorylation,
pubmed-meshheading:10725920-Rats,
pubmed-meshheading:10725920-Rats, Sprague-Dawley,
pubmed-meshheading:10725920-Stimulation, Chemical,
pubmed-meshheading:10725920-Synapsins,
pubmed-meshheading:10725920-Synaptic Transmission,
pubmed-meshheading:10725920-Synaptosomes
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pubmed:year |
2000
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pubmed:articleTitle |
Synapsins as mediators of BDNF-enhanced neurotransmitter release.
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pubmed:affiliation |
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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