Linked Life Data

10725813

Source:http://linkedlifedata.com/resource/pubmed/id/10725813

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-7-7
pubmed:abstractText
Metalloproteinase-mediated proteolysis plays an important role during the phase of venous ulcer formation and wound repair. Venous ulcers manifest as a breakdown of the collagenous stromal tissue and are highly associated to chronic venous insufficiency. A major change in our understanding of the pathogenesis of venous ulcers occurred with the demonstration of extracellular matrix-degrading activity of matrix metalloproteinases to generate a dermal-epidermal skin defect. These proteases were intensely investigated in preceding stages and during wound repair of venous ulcerations. Different studies have revealed their significance in the process of proteolytic remodeling and recognized their potential importance in finding therapeutic rationales to manage late complications of chronic venous ulcers.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1167-1122
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
173-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Matrix metalloproteinases and venous leg ulceration.
pubmed:affiliation
Department of Dermatology, University Hospital, Hauptstr. 7, 79104-Freiburg, Germany. herouy@haut.ukl.uni-freiburg.de.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't