Linked Life Data

10725754

Source:http://linkedlifedata.com/resource/pubmed/id/10725754

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2000-5-4
pubmed:abstractText
Previous work has indicated that an important component for the initiation of autoimmune insulin-dependent diabetes mellitus (IDDM) in the NOD mouse model entails MHC class I-restricted CD8 T cell responses against pancreatic beta cell Ags. However, unless previously activated in vitro, such CD8 T cells have previously been thought to require helper functions provided by MHC class II-restricted CD4 T cells to exert their full diabetogenic effects. In this study, we show that IDDM development is greatly accelerated in a stock of NOD mice expressing TCR transgenes derived from a MHC class I-restricted CD8 T cell clone (designated AI4) previously found to contribute to the earliest preclinical stages of pancreatic beta cell destruction. Importantly, these TCR transgenic NOD mice (designated NOD.AI4alphabeta Tg) continued to develop IDDM at a greatly accelerated rate when residual CD4 helper T cells were eliminated by introduction of the scid mutation or a functionally inactivated CD4 allele. In a previously described stock of NOD mice expressing TCR transgenes derived from another MHC class I-restricted beta cell autoreactive T cell clone, IDDM development was retarded by elimination of residual CD4 T cells. Hence, there is variability in the helper dependence of CD8 T cells contributing to the development of autoimmune IDDM. The AI4 clonotype represents the first CD8 T cell with a demonstrated ability to progress from a naive to functionally activated state and rapidly mediate autoimmune IDDM development in the complete absence of CD4 T cell helper functions.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
164
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3913-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:10725754-Animals, pubmed-meshheading:10725754-CD4-Positive T-Lymphocytes, pubmed-meshheading:10725754-CD8-Positive T-Lymphocytes, pubmed-meshheading:10725754-Cell Lineage, pubmed-meshheading:10725754-Clone Cells, pubmed-meshheading:10725754-Diabetes Mellitus, Type 1, pubmed-meshheading:10725754-Female, pubmed-meshheading:10725754-Gene Expression Regulation, pubmed-meshheading:10725754-Histocompatibility Antigens Class I, pubmed-meshheading:10725754-Islets of Langerhans, pubmed-meshheading:10725754-Mice, pubmed-meshheading:10725754-Mice, Inbred NOD, pubmed-meshheading:10725754-Mice, SCID, pubmed-meshheading:10725754-Mice, Transgenic, pubmed-meshheading:10725754-Receptors, Antigen, T-Cell, alpha-beta, pubmed-meshheading:10725754-T-Lymphocytes, Helper-Inducer, pubmed-meshheading:10725754-Transgenes
pubmed:year
2000
pubmed:articleTitle
Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions.
pubmed:affiliation
The Jackson Laboratory, Bar Harbor, ME 04609, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't