| pubmed-article:10725709 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10725709 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10725709 | lifeskim:mentions | umls-concept:C1326230 | lld:lifeskim |
| pubmed-article:10725709 | lifeskim:mentions | umls-concept:C2698596 | lld:lifeskim |
| pubmed-article:10725709 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:10725709 | pubmed:dateCreated | 2000-5-4 | lld:pubmed |
| pubmed-article:10725709 | pubmed:abstractText | The effect of B7-mediated costimulation on T cell homeostasis was examined in studies of B7-1 (CD80) and B7-2 (CD86) transgenic as well as B7-deficient mice. B7 overexpression in transgenic mice resulted in marked polyclonal peripheral T cell hyperplasia accompanied by skewing toward an increased proportion of CD8 single-positive cells and a decreased proportion of CD4 single-positive cells in thymus and more markedly in peripheral T cells. B7-induced T cell expansion was dependent on both CD28 and TCR expression. Transgenic overexpression of B7-1 or B7-2 resulted in down-regulation of cell surface CD28 on thymocytes and peripheral T cells through a mechanism mediated by intercellular interaction. Mice deficient in B7-1 and B7-2 exhibited changes that were the reciprocal of those observed in B7-overexpressing transgenics: a marked increase in the CD4/CD8 ratio in peripheral T cells and an increase in cell surface CD28 in thymus and peripheral T cells. These reciprocal effects of genetically engineered increase or decrease in B7 expression indicate that B7 costimulation plays a physiological role in the regulation of CD4+ and CD8+ T cell homeostasis. | lld:pubmed |
| pubmed-article:10725709 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10725709 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10725709 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:10725709 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10725709 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10725709 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10725709 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10725709 | pubmed:author | pubmed-author:HodesR JRJ | lld:pubmed |
| pubmed-article:10725709 | pubmed:author | pubmed-author:AllisonJ PJP | lld:pubmed |
| pubmed-article:10725709 | pubmed:author | pubmed-author:FournierSS | lld:pubmed |
| pubmed-article:10725709 | pubmed:author | pubmed-author:SharpeA HAH | lld:pubmed |
| pubmed-article:10725709 | pubmed:author | pubmed-author:YuXX | lld:pubmed |
| pubmed-article:10725709 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10725709 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10725709 | pubmed:volume | 164 | lld:pubmed |
| pubmed-article:10725709 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10725709 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10725709 | pubmed:pagination | 3543-53 | lld:pubmed |
| pubmed-article:10725709 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:10725709 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10725709 | pubmed:articleTitle | The role of B7 costimulation in CD4/CD8 T cell homeostasis. | lld:pubmed |
| pubmed-article:10725709 | pubmed:affiliation | Experimental Immunology Branch, National Cancer Institute, and National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA. yux@intra.nei.nih.gov | lld:pubmed |
| pubmed-article:10725709 | pubmed:publicationType | Journal Article | lld:pubmed |
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