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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2000-5-4
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pubmed:abstractText |
The effect of B7-mediated costimulation on T cell homeostasis was examined in studies of B7-1 (CD80) and B7-2 (CD86) transgenic as well as B7-deficient mice. B7 overexpression in transgenic mice resulted in marked polyclonal peripheral T cell hyperplasia accompanied by skewing toward an increased proportion of CD8 single-positive cells and a decreased proportion of CD4 single-positive cells in thymus and more markedly in peripheral T cells. B7-induced T cell expansion was dependent on both CD28 and TCR expression. Transgenic overexpression of B7-1 or B7-2 resulted in down-regulation of cell surface CD28 on thymocytes and peripheral T cells through a mechanism mediated by intercellular interaction. Mice deficient in B7-1 and B7-2 exhibited changes that were the reciprocal of those observed in B7-overexpressing transgenics: a marked increase in the CD4/CD8 ratio in peripheral T cells and an increase in cell surface CD28 in thymus and peripheral T cells. These reciprocal effects of genetically engineered increase or decrease in B7 expression indicate that B7 costimulation plays a physiological role in the regulation of CD4+ and CD8+ T cell homeostasis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD86,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Cd86 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
164
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3543-53
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:10725709-Animals,
pubmed-meshheading:10725709-Antigens, CD,
pubmed-meshheading:10725709-Antigens, CD28,
pubmed-meshheading:10725709-Antigens, CD80,
pubmed-meshheading:10725709-Antigens, CD86,
pubmed-meshheading:10725709-Antigens, Differentiation,
pubmed-meshheading:10725709-CD4-CD8 Ratio,
pubmed-meshheading:10725709-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10725709-CD8-Positive T-Lymphocytes,
pubmed-meshheading:10725709-CTLA-4 Antigen,
pubmed-meshheading:10725709-Down-Regulation,
pubmed-meshheading:10725709-Homeostasis,
pubmed-meshheading:10725709-Hyperplasia,
pubmed-meshheading:10725709-Immunoconjugates,
pubmed-meshheading:10725709-Lymphocyte Activation,
pubmed-meshheading:10725709-Lymphoid Tissue,
pubmed-meshheading:10725709-Membrane Glycoproteins,
pubmed-meshheading:10725709-Mice,
pubmed-meshheading:10725709-Mice, Congenic,
pubmed-meshheading:10725709-Mice, Inbred BALB C,
pubmed-meshheading:10725709-Mice, Inbred C57BL,
pubmed-meshheading:10725709-Mice, Mutant Strains,
pubmed-meshheading:10725709-Mice, Transgenic,
pubmed-meshheading:10725709-Phenotype,
pubmed-meshheading:10725709-Receptors, Antigen, T-Cell,
pubmed-meshheading:10725709-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:10725709-T-Lymphocyte Subsets
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pubmed:year |
2000
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pubmed:articleTitle |
The role of B7 costimulation in CD4/CD8 T cell homeostasis.
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pubmed:affiliation |
Experimental Immunology Branch, National Cancer Institute, and National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA. yux@intra.nei.nih.gov
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pubmed:publicationType |
Journal Article
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