Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-5-11
pubmed:databankReference
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF205408, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF205409, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF205410, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF205411, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF205412, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF205413, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF205414, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF205415, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF205416, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF205417, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF205418, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF205419, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF205420, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF205421
pubmed:abstractText
Certain mutations are known to occur with differing frequencies on the leading and lagging strands of DNA. The extent to which these mutational biases affect the sequences of higher eukaryotes has been difficult to ascertain because the positions of most replication origins are not known, making it impossible to distinguish between the leading and lagging strands. To resolve whether strand biases influence the evolution of primate sequences, we compared the substitution patterns in noncoding regions adjacent to an origin of replication identified within the beta-globin complex. Although there was limited asymmetry around the beta-globin origin of replication, patterns of substitutions do not support the existence of a mutational bias between the leading and lagging strands of chromosomal DNA replication in primates.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0737-4038
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
416-22
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Strand symmetry around the beta-globin origin of replication in primates.
pubmed:affiliation
Department of Biology, University of Rochester.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.