Linked Life Data

10722885

Source:http://linkedlifedata.com/resource/pubmed/id/10722885

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-6-2
pubmed:abstractText
The oestrogenic activity of the parabens, methyl-, ethyl- and propyl p-hydroxybenzoate, widely used as antimicrobials in food, and butyl p-hydroxybenzoate, which is used in cosmetic products, and their shared main metabolite p-hydroxybenzoic acid was investigated in a mouse uterotrophic assay. Immature B6D2F1 mice were treated with oral or subcutaneous doses of the test compounds for three consecutive days. p-Hydroxybenzoic acid and butyl p-hydroxybenzoate were also tested by the subcutaneous route in a rat uterotrophic assay. A significant increase in the uterus weight at day 4 was considered an oestrogenic effect. In the mouse assay, none of the compounds tested produced any oestrogenic response at dose levels up to 100mg/kg body weight per day, for ethyl p-hydroxybenzoate even at a dose level of 1000mg/kg body weight per day. In immature Wistar rats, subcutaneous administration of butyl p-hydroxybenzoate produced a weak oestrogenic response at 600mg/kg body weight per day.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0278-6915
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
319-23
pubmed:dateRevised
2006-3-13
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Lack of oestrogenic effects of food preservatives (parabens) in uterotrophic assays.
pubmed:affiliation
Institute of Food Safety and Toxicology, Danish Veterinary and Food Administration, Morkhoj Bygade 19, 2860 Soborg, Denmark. ALH@VFD.DK
pubmed:publicationType
Journal Article