| pubmed-article:10722729 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10722729 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:10722729 | lifeskim:mentions | umls-concept:C0005388 | lld:lifeskim |
| pubmed-article:10722729 | lifeskim:mentions | umls-concept:C0035339 | lld:lifeskim |
| pubmed-article:10722729 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:10722729 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:10722729 | lifeskim:mentions | umls-concept:C0596902 | lld:lifeskim |
| pubmed-article:10722729 | lifeskim:mentions | umls-concept:C0040624 | lld:lifeskim |
| pubmed-article:10722729 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:10722729 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:10722729 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:10722729 | pubmed:dateCreated | 2000-4-27 | lld:pubmed |
| pubmed-article:10722729 | pubmed:abstractText | Cytokines have been implicated in the pathogenesis of inflammatory cholestasis. This is due to transcriptional down-regulation of hepatic transporters including the Na(+)/bile acid cotransporter, ntcp, and the multispecific organic anion exporter, mrp2. We have recently shown that ntcp suppression by lipopolysaccharide in vivo is caused by down-regulation of transactivators including the previously uncharacterized Footprint B-binding protein. Both the ntcp FpB element and the mrp2 promoter contain potential retinoid-response elements. We hypothesized that retinoic acid receptor (RAR) and retinoid X receptor (RXR) heterodimers would activate these two genes and that cytokines that reduce bile flow might do so by suppressing nuclear levels of these transactivators. Retinoid transactivation and interleukin-1beta down-regulation of the ntcp and mrp2 promoters were mapped to RXRalpha:RARalpha-response elements. Gel mobility shift assays demonstrated specific binding of RXRalpha:RARalpha heterodimers to the ntcp and mrp2 retinoid-response elements. The RXRalpha:RARalpha complex was down-regulated by IL-1beta in HepG2 cells. An unexpected finding was that an adjacent CAAT-enhancer-binding protein element was required for maximal transactivation of the ntcp promoter by RXRalpha:RARalpha. Taken together, these studies demonstrate regulation of two hepatobiliary transporter genes by RXRalpha:RARalpha and describe a mechanism which likely contributes to their down-regulation during inflammation. | lld:pubmed |
| pubmed-article:10722729 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10722729 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10722729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10722729 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10722729 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:10722729 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10722729 | pubmed:author | pubmed-author:MangelsdorfD... | lld:pubmed |
| pubmed-article:10722729 | pubmed:author | pubmed-author:McClureM HMH | lld:pubmed |
| pubmed-article:10722729 | pubmed:author | pubmed-author:AuldK LKL | lld:pubmed |
| pubmed-article:10722729 | pubmed:author | pubmed-author:KarpenS JSJ | lld:pubmed |
| pubmed-article:10722729 | pubmed:author | pubmed-author:DensonL ALA | lld:pubmed |
| pubmed-article:10722729 | pubmed:author | pubmed-author:SchiekD SDS | lld:pubmed |
| pubmed-article:10722729 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10722729 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:10722729 | pubmed:volume | 275 | lld:pubmed |
| pubmed-article:10722729 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10722729 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10722729 | pubmed:pagination | 8835-43 | lld:pubmed |
| pubmed-article:10722729 | pubmed:dateRevised | 2010-8-9 | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:meshHeading | pubmed-meshheading:10722729... | lld:pubmed |
| pubmed-article:10722729 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10722729 | pubmed:articleTitle | Interleukin-1beta suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation. | lld:pubmed |
| pubmed-article:10722729 | pubmed:affiliation | Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA. | lld:pubmed |
| pubmed-article:10722729 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10722729 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10722729 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10722729 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10722729 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10722729 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10722729 | lld:pubmed |
