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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2000-5-1
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pubmed:abstractText |
We studied the effect on viral growth of drugs targeting different virus functions using a computer simulation for the intracellular growth of bacteriophage T7. We found that drugs targeting components of negative-feedback loops gain effectiveness against mutant viruses that attenuate the drug-target interaction. The greater inhibition of such mutants than of the wild type suggests a drug design strategy that would hinder the development of drug resistance.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722522-10202827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722522-1280997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722522-1716689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722522-2542566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722522-6207934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722522-7534907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722522-7563086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722522-7692302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722522-8107264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722522-8551567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722522-8558989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722522-8599114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722522-8650227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722522-9192676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722522-9204684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722522-9447596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722522-9643550
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1097-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10722522-Antiviral Agents,
pubmed-meshheading:10722522-Bacteriophage T7,
pubmed-meshheading:10722522-Computer Simulation,
pubmed-meshheading:10722522-Drug Resistance, Microbial,
pubmed-meshheading:10722522-Escherichia coli,
pubmed-meshheading:10722522-RNA, Antisense,
pubmed-meshheading:10722522-RNA, Viral,
pubmed-meshheading:10722522-Viruses
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pubmed:year |
2000
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pubmed:articleTitle |
Toward antiviral strategies that resist viral escape.
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pubmed:affiliation |
Department of Chemical Engineering, University of Wisconsin-Madison, Madison, WI 53706-1691, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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