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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2000-5-1
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pubmed:databankReference |
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pubmed:abstractText |
A clinical isolate of Helicobacter pylori that developed resistance to rifabutin during therapy carried an rpoB gene that retained a wild-type cluster region sequence but had acquired a novel codon 149 (V149F) mutation. In transformation experiments, the mutation was shown to confer high-level rifabutin resistance. The equivalent mutation (V176F) was present in several resistant isolates of Mycobacterium tuberculosis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722516-10223916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722516-10348780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722516-6384726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722516-8027320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722516-8052230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722516-8095569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722516-8325861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722516-8665467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722516-8849230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722516-9114427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722516-9252185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722516-9431913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722516-9660694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722516-9661032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722516-9661035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10722516-9848446
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1075-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10722516-Amino Acid Sequence,
pubmed-meshheading:10722516-Anti-Bacterial Agents,
pubmed-meshheading:10722516-Codon,
pubmed-meshheading:10722516-DNA-Directed RNA Polymerases,
pubmed-meshheading:10722516-Drug Resistance,
pubmed-meshheading:10722516-Helicobacter pylori,
pubmed-meshheading:10722516-Molecular Sequence Data,
pubmed-meshheading:10722516-Mutation,
pubmed-meshheading:10722516-Mycobacterium tuberculosis,
pubmed-meshheading:10722516-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10722516-Rifamycins
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pubmed:year |
2000
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pubmed:articleTitle |
Mutations in the beginning of the rpoB gene can induce resistance to rifamycins in both Helicobacter pylori and Mycobacterium tuberculosis.
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pubmed:affiliation |
Institute for Medical Microbiology, Regensburg, Germany. Markus.Heep@klinik.uni-regensburg.de
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pubmed:publicationType |
Journal Article
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