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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2000-4-3
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pubmed:abstractText |
Dendritic cells (DC) capture microorganisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present these in antigenic form to resting T cells and thus initiate adaptive immune responses. Here, we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC but instead promotes efficient infection in trans of cells that express CD4 and chemokine receptors. We propose that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0092-8674
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pubmed:author |
pubmed-author:CornelissenI LIL,
pubmed-author:FigdorC GCG,
pubmed-author:GeijtenbeekT BTB,
pubmed-author:KewalRamaniV NVN,
pubmed-author:KwonD SDS,
pubmed-author:LittmanD RDR,
pubmed-author:MiddelJJ,
pubmed-author:NottetH SHS,
pubmed-author:TorensmaRR,
pubmed-author:van DuijnhovenG CGC,
pubmed-author:van KooykYY,
pubmed-author:van VlietS JSJ
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
587-97
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10721995-Antigens, CD4,
pubmed-meshheading:10721995-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10721995-Cell Adhesion Molecules,
pubmed-meshheading:10721995-Cell Movement,
pubmed-meshheading:10721995-Cells, Cultured,
pubmed-meshheading:10721995-Cervix Uteri,
pubmed-meshheading:10721995-Coculture Techniques,
pubmed-meshheading:10721995-Dendritic Cells,
pubmed-meshheading:10721995-Female,
pubmed-meshheading:10721995-HIV Envelope Protein gp120,
pubmed-meshheading:10721995-HIV Infections,
pubmed-meshheading:10721995-HIV-1,
pubmed-meshheading:10721995-Humans,
pubmed-meshheading:10721995-Lectins,
pubmed-meshheading:10721995-Lymph Nodes,
pubmed-meshheading:10721995-Lymphoid Tissue,
pubmed-meshheading:10721995-Macromolecular Substances,
pubmed-meshheading:10721995-Male,
pubmed-meshheading:10721995-Mucous Membrane,
pubmed-meshheading:10721995-Receptors, CCR5,
pubmed-meshheading:10721995-Receptors, HIV,
pubmed-meshheading:10721995-Rectum,
pubmed-meshheading:10721995-Transfection,
pubmed-meshheading:10721995-Uterus
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pubmed:year |
2000
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pubmed:articleTitle |
DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.
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pubmed:affiliation |
Department of Tumor Immunology, University Medical Center St. Radboud, Nijmegen, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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