Linked Life Data

10720751

Source:http://linkedlifedata.com/resource/pubmed/id/10720751

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2000-5-4
pubmed:abstractText
N-Acetyltransferases (EC 2.3.1.5) are important in both the activation and deactivation of aromatic and heterocyclic amine carcinogens. Two N-acetyltransferase isozymes (NAT1 and NAT2) encoded by NAT1 and NAT2, respectively, have been identified. Both NAT1 and NAT2 exhibit genetic polymorphisms, and recent investigations have increased our understanding of the relationship between genotype and phenotype. Several studies have shown a role for NAT1 and NAT2 acetylation polymorphisms in cancer risk in human populations, but the findings have been inconsistent. These findings may relate to variability in carcinogen exposures and to differences in acetylator genotype/phenotype determinations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0378-4274
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
112-113
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
349-56
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
N-Acetyltransferase genetics and their role in predisposition to aromatic and heterocyclic amine-induced carcinogenesis.
pubmed:affiliation
Department of Pharmacology, University of Louisville School of Medicine, Louisville, KY, USA. d.hein@louisville.edu
pubmed:publicationType
Journal Article, Review