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rdf:type |
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lifeskim:mentions |
umls-concept:C0005821,
umls-concept:C0022702,
umls-concept:C0040052,
umls-concept:C0079411,
umls-concept:C0086418,
umls-concept:C0205263,
umls-concept:C1335872,
umls-concept:C1335875,
umls-concept:C1335876,
umls-concept:C1367307,
umls-concept:C1704241
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pubmed:issue |
3
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pubmed:dateCreated |
2000-4-24
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pubmed:abstractText |
Thrombopoietin (TPO) is the pivotal regulator of thrombocytopoiesis and megakaryocytopoiesis, and binding to its receptor c-Mpl leads to activation of at least two different signaling pathways: the Jak-Stat pathway and the Ras-MAPK pathway. Our aim was to elucidate which Stat-complexes are formed in TPO signal transduction in human blood platelets.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Milk Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/STAT5 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT5A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/STAT5B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Thrombopoietin,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0301-472X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
294-304
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10720694-Blood Platelets,
pubmed-meshheading:10720694-DNA-Binding Proteins,
pubmed-meshheading:10720694-Dimerization,
pubmed-meshheading:10720694-Humans,
pubmed-meshheading:10720694-Milk Proteins,
pubmed-meshheading:10720694-Platelet Activation,
pubmed-meshheading:10720694-Protein Binding,
pubmed-meshheading:10720694-STAT1 Transcription Factor,
pubmed-meshheading:10720694-STAT3 Transcription Factor,
pubmed-meshheading:10720694-STAT5 Transcription Factor,
pubmed-meshheading:10720694-Signal Transduction,
pubmed-meshheading:10720694-Thrombopoietin,
pubmed-meshheading:10720694-Trans-Activators,
pubmed-meshheading:10720694-Tumor Suppressor Proteins
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pubmed:year |
2000
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pubmed:articleTitle |
Thrombopoietin induces the generation of distinct Stat1, Stat3, Stat5a and Stat5b homo- and heterodimeric complexes with different kinetics in human platelets.
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pubmed:affiliation |
Department of Pediatric Hematology and Oncology, Medical School Hannover, Hannover, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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