Source:http://linkedlifedata.com/resource/pubmed/id/10719886
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2000-3-30
|
| pubmed:abstractText |
Motor axons form topographic maps on muscles: rostral motor pools innervate rostral muscles, and rostral portions of motor pools innervate rostral fibers within their targets. Here, we implicate A subfamily ephrins in this topographic mapping. First, developing muscles express all five of the ephrin-A genes. Second, rostrally and caudally derived motor axons differ in sensitivity to outgrowth inhibition by ephrin-A5. Third, the topographic map of motor axons on the gluteus muscle is degraded in transgenic mice that overexpress ephrin-A5 in muscles. Fourth, topographic mapping is impaired in muscles of mutant mice lacking ephrin-A2 plus ephrin-A5. Thus, ephrins mediate or modulate positionally selective synapse formation. In addition, the rostrocaudal position of at least one motor pool is altered in ephrin-A5 mutant mice, indicating that ephrins affect nerve-muscle matching by intraspinal as well as intramuscular mechanisms.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0896-6273
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
295-306
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:10719886-Animals,
pubmed-meshheading:10719886-Axons,
pubmed-meshheading:10719886-Cell Communication,
pubmed-meshheading:10719886-Cells, Cultured,
pubmed-meshheading:10719886-Ephrin-A2,
pubmed-meshheading:10719886-Ephrin-A5,
pubmed-meshheading:10719886-Fibroblasts,
pubmed-meshheading:10719886-Gene Expression,
pubmed-meshheading:10719886-Membrane Proteins,
pubmed-meshheading:10719886-Mice,
pubmed-meshheading:10719886-Mice, Inbred C57BL,
pubmed-meshheading:10719886-Mice, Inbred CBA,
pubmed-meshheading:10719886-Mice, Knockout,
pubmed-meshheading:10719886-Motor Neurons,
pubmed-meshheading:10719886-Muscle, Skeletal,
pubmed-meshheading:10719886-Muscle Fibers, Skeletal,
pubmed-meshheading:10719886-Neuromuscular Junction,
pubmed-meshheading:10719886-Spinal Cord,
pubmed-meshheading:10719886-Synapses,
pubmed-meshheading:10719886-Transcription Factors
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Roles for ephrins in positionally selective synaptogenesis between motor neurons and muscle fibers.
|
| pubmed:affiliation |
Department of Anatomy, Washington University Medical School, St. Louis, Missouri 63110, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|