Linked Life Data

10719148

Source:http://linkedlifedata.com/resource/pubmed/id/10719148

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2000-5-17
pubmed:abstractText
Retroviruses are biologically complex infectious agents which are capable of cellular infection and subsequent integration into the host genome. Retroviruses can exist in an endogenous form in which viral sequences are integrated into the human germline and are vertically transmitted in a Mendelian fashion. The transcriptional activation of these viral sequences in cells within the central nervous system can affect the transcriptional regulation of adjacent genes and result in alterations of neural functioning. This report discusses evidence for a possible role of endogenous retroviruses in the etiopathogenesis of schizophrenia and other human brain diseases. Evidence of endogenous retrovirus activity is manifested by the identification of viral sequences in the brains and cerebrospinal fluids of affected individuals. In addition, affected individuals display evidence of increased activity of virally-encoded reverse transcriptase. The identification of a retroviral component of schizophrenia would be consistent with genetic, environmental, and neurodevelopmental aspects of the disease process. The delineation of a role for retroviruses in disease pathogenesis might lead to new methods for the diagnosis and treatment of schizophrenia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:author
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
193-9
pubmed:dateRevised
2007-2-26
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Endogenous retroviruses and schizophrenia.
pubmed:affiliation
Johns Hopkins University School of Medicine, Stanley Division of Developmental Neurovirology, Department of Pediatrics, 600 N. Wolfe Street, Blalock 1111, Baltimore, MD, USA. yolken@welchlink.welch.jhu.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't