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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-5-15
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pubmed:abstractText |
Both in vivo and in vitro evidence indicates that primary hyperparathyroidism is characterized by a reduced sensitivity to extracellular calcium ([Ca2+]o). The existence of alterations in the expression and signalling of calcium sensing receptor (CaSR) in parathyroid neoplasia is still uncertain. In order to clarify the role of CaSR in the reduced [Ca2+]o sensing of parathyroid neoplasia we investigated PTH secretion and intracellular effectors triggered by CaSR activation as well as the levels of expression of CaSR and CaSR coupled G proteins (Gq/G11) in parathyroid adenomas and primary hyperplasia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0300-0664
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
339-48
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10718832-Adenoma,
pubmed-meshheading:10718832-Adult,
pubmed-meshheading:10718832-Aged,
pubmed-meshheading:10718832-Analysis of Variance,
pubmed-meshheading:10718832-Blotting, Western,
pubmed-meshheading:10718832-Calcium,
pubmed-meshheading:10718832-Cells, Cultured,
pubmed-meshheading:10718832-Cyclic AMP,
pubmed-meshheading:10718832-Female,
pubmed-meshheading:10718832-Humans,
pubmed-meshheading:10718832-Hyperplasia,
pubmed-meshheading:10718832-Male,
pubmed-meshheading:10718832-Middle Aged,
pubmed-meshheading:10718832-Parathyroid Glands,
pubmed-meshheading:10718832-Parathyroid Hormone,
pubmed-meshheading:10718832-Parathyroid Neoplasms,
pubmed-meshheading:10718832-Receptors, Calcium-Sensing,
pubmed-meshheading:10718832-Receptors, Cell Surface,
pubmed-meshheading:10718832-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10718832-Signal Transduction
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pubmed:year |
2000
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pubmed:articleTitle |
Calcium-sensing receptor expression and signalling in human parathyroid adenomas and primary hyperplasia.
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pubmed:affiliation |
Institute of Endocrine Sciences, University of Milan, Milan, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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