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pubmed-article:10716947pubmed:abstractTextCaenorhabditis elegans mab-9 mutants are defective in hindgut and male tail development because of cell fate transformations in two posterior blast cells, B and F. We have cloned mab-9 and show that it encodes a member of the T-box family of transcriptional regulators. MAB-9 localizes to the nucleus of B and F and their descendents during development, suggesting that it acts cell autonomously in the posterior hindgut to direct cell fate. T-box genes related to brachyury have also been implicated in hindgut patterning, and our results support models for an evolutionarily ancient role for these genes in hindgut formation.lld:pubmed
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pubmed-article:10716947pubmed:articleTitleThe caenorhabditis elegans fate-determining gene mab-9 encodes a T-box protein required to pattern the posterior hindgut.lld:pubmed
pubmed-article:10716947pubmed:affiliationMedical Research Council (MRC) Laboratory of Molecular Biology (LMB), Cambridge CB2 2QH, UK. woollard@bioch.ox.ac.uklld:pubmed
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