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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0033684,
umls-concept:C0162610,
umls-concept:C0205095,
umls-concept:C0231053,
umls-concept:C0449774,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C2700640
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pubmed:issue |
5
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pubmed:dateCreated |
2000-4-24
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pubmed:abstractText |
Caenorhabditis elegans mab-9 mutants are defective in hindgut and male tail development because of cell fate transformations in two posterior blast cells, B and F. We have cloned mab-9 and show that it encodes a member of the T-box family of transcriptional regulators. MAB-9 localizes to the nucleus of B and F and their descendents during development, suggesting that it acts cell autonomously in the posterior hindgut to direct cell fate. T-box genes related to brachyury have also been implicated in hindgut patterning, and our results support models for an evolutionarily ancient role for these genes in hindgut formation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-10049576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-10203826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-10457009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-10511553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-1497674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-1689462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-1879361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-2154694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-2606353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-6684600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-7409314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-7600949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-7958884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-838129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-8625826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-9012492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-9168109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-9276934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-9309177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-9374390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-9486653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-9503012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-9647634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-9808786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-9834188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-9851920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10716947-9851921
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0890-9369
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
596-603
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10716947-Amino Acid Sequence,
pubmed-meshheading:10716947-Animals,
pubmed-meshheading:10716947-Body Patterning,
pubmed-meshheading:10716947-Caenorhabditis elegans,
pubmed-meshheading:10716947-Caenorhabditis elegans Proteins,
pubmed-meshheading:10716947-Cell Nucleus,
pubmed-meshheading:10716947-Cloning, Molecular,
pubmed-meshheading:10716947-Drosophila,
pubmed-meshheading:10716947-Gene Expression Regulation, Developmental,
pubmed-meshheading:10716947-Genes, Helminth,
pubmed-meshheading:10716947-Humans,
pubmed-meshheading:10716947-Male,
pubmed-meshheading:10716947-Mice,
pubmed-meshheading:10716947-Molecular Sequence Data,
pubmed-meshheading:10716947-Promoter Regions, Genetic,
pubmed-meshheading:10716947-Recombinant Proteins,
pubmed-meshheading:10716947-Sequence Alignment,
pubmed-meshheading:10716947-Sequence Homology, Amino Acid,
pubmed-meshheading:10716947-Tail,
pubmed-meshheading:10716947-Transcription Factors
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pubmed:year |
2000
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pubmed:articleTitle |
The caenorhabditis elegans fate-determining gene mab-9 encodes a T-box protein required to pattern the posterior hindgut.
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pubmed:affiliation |
Medical Research Council (MRC) Laboratory of Molecular Biology (LMB), Cambridge CB2 2QH, UK. woollard@bioch.ox.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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