| pubmed-article:10714681 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10714681 | lifeskim:mentions | umls-concept:C1155065 | lld:lifeskim |
| pubmed-article:10714681 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:10714681 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:10714681 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:10714681 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:10714681 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:10714681 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:10714681 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:10714681 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:10714681 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10714681 | pubmed:dateCreated | 2000-4-7 | lld:pubmed |
| pubmed-article:10714681 | pubmed:abstractText | Vav and PKCtheta play an early and important role in the TCR/CD28-induced stimulation of MAP kinases and activation of the IL-2 gene. Vav is also essential for actin cytoskeleton reorganization and TCR capping. Here, we report that PKCtheta function was selectively required in a Vav signaling pathway that mediates the TCR/CD28-induced activation of JNK and the IL-2 gene and the upregulation of CD69 expression. Vav also promoted PKCtheta translocation from the cytosol to the membrane and cytoskeleton and induced its enzymatic activation in a CD3/CD28-initiated pathway that was dependent on Rac and on actin cytoskeleton reorganization. These findings reveal that the Vav/Rac pathway promotes the recruitment of PKCtheta to the T cell synapse and its activation, essential processes for T cell activation and IL-2 production. | lld:pubmed |
| pubmed-article:10714681 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10714681 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10714681 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10714681 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10714681 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10714681 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10714681 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10714681 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10714681 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10714681 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10714681 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10714681 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10714681 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10714681 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10714681 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10714681 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10714681 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10714681 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10714681 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:10714681 | pubmed:author | pubmed-author:AltmanAA | lld:pubmed |
| pubmed-article:10714681 | pubmed:author | pubmed-author:MasPP | lld:pubmed |
| pubmed-article:10714681 | pubmed:author | pubmed-author:VillalbaMM | lld:pubmed |
| pubmed-article:10714681 | pubmed:author | pubmed-author:DeckertMM | lld:pubmed |
| pubmed-article:10714681 | pubmed:author | pubmed-author:TeixeiroEE | lld:pubmed |
| pubmed-article:10714681 | pubmed:author | pubmed-author:CoudronniereN... | lld:pubmed |
| pubmed-article:10714681 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10714681 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:10714681 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10714681 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10714681 | pubmed:pagination | 151-60 | lld:pubmed |
| pubmed-article:10714681 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:10714681 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10714681 | pubmed:articleTitle | A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation. | lld:pubmed |
| pubmed-article:10714681 | pubmed:affiliation | Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA. | lld:pubmed |
| pubmed-article:10714681 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10714681 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10714681 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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