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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-4-7
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pubmed:abstractText |
Vav and PKCtheta play an early and important role in the TCR/CD28-induced stimulation of MAP kinases and activation of the IL-2 gene. Vav is also essential for actin cytoskeleton reorganization and TCR capping. Here, we report that PKCtheta function was selectively required in a Vav signaling pathway that mediates the TCR/CD28-induced activation of JNK and the IL-2 gene and the upregulation of CD69 expression. Vav also promoted PKCtheta translocation from the cytosol to the membrane and cytoskeleton and induced its enzymatic activation in a CD3/CD28-initiated pathway that was dependent on Rac and on actin cytoskeleton reorganization. These findings reveal that the Vav/Rac pathway promotes the recruitment of PKCtheta to the T cell synapse and its activation, essential processes for T cell activation and IL-2 production.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD69 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/PRKCQ protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-vav,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/VAV1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/rac GTP-Binding Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
151-60
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10714681-Actins,
pubmed-meshheading:10714681-Animals,
pubmed-meshheading:10714681-Antigens, CD,
pubmed-meshheading:10714681-Antigens, CD28,
pubmed-meshheading:10714681-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:10714681-Biological Transport,
pubmed-meshheading:10714681-Cell Cycle Proteins,
pubmed-meshheading:10714681-Cell Membrane,
pubmed-meshheading:10714681-Enzyme Activation,
pubmed-meshheading:10714681-Gene Expression Regulation,
pubmed-meshheading:10714681-Humans,
pubmed-meshheading:10714681-Interleukin-2,
pubmed-meshheading:10714681-Isoenzymes,
pubmed-meshheading:10714681-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:10714681-Jurkat Cells,
pubmed-meshheading:10714681-Lectins, C-Type,
pubmed-meshheading:10714681-Lymphocyte Activation,
pubmed-meshheading:10714681-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10714681-Protein Kinase C,
pubmed-meshheading:10714681-Proto-Oncogene Proteins,
pubmed-meshheading:10714681-Proto-Oncogene Proteins c-vav,
pubmed-meshheading:10714681-Rabbits,
pubmed-meshheading:10714681-Receptors, Antigen, T-Cell,
pubmed-meshheading:10714681-T-Lymphocytes,
pubmed-meshheading:10714681-Transcriptional Activation,
pubmed-meshheading:10714681-Up-Regulation,
pubmed-meshheading:10714681-rac GTP-Binding Proteins
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pubmed:year |
2000
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pubmed:articleTitle |
A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation.
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pubmed:affiliation |
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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