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rdf:type |
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lifeskim:mentions |
umls-concept:C0006456,
umls-concept:C0013227,
umls-concept:C0021853,
umls-concept:C0030956,
umls-concept:C0034693,
umls-concept:C0162969,
umls-concept:C0282560,
umls-concept:C0332161,
umls-concept:C0596019,
umls-concept:C1515655,
umls-concept:C1533691,
umls-concept:C1823138
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pubmed:issue |
1
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pubmed:dateCreated |
2000-3-23
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pubmed:abstractText |
To evaluate N-trimethyl chitosan chloride (TMC) of high degrees of substitution as intestinal permeation enhancers for the peptide drug buserelin in vitro using Caco-2 cell monolayers, and to investigate TMCs as enhancers of the intestinal absorption of buserelin in vivo, in rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0724-8741
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
27-31
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10714604-Animals,
pubmed-meshheading:10714604-Biological Transport,
pubmed-meshheading:10714604-Buserelin,
pubmed-meshheading:10714604-Caco-2 Cells,
pubmed-meshheading:10714604-Chitin,
pubmed-meshheading:10714604-Chitosan,
pubmed-meshheading:10714604-Drug Carriers,
pubmed-meshheading:10714604-Humans,
pubmed-meshheading:10714604-Hydrogen-Ion Concentration,
pubmed-meshheading:10714604-Intestinal Absorption,
pubmed-meshheading:10714604-Male,
pubmed-meshheading:10714604-Rats,
pubmed-meshheading:10714604-Rats, Wistar
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pubmed:year |
2000
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pubmed:articleTitle |
N-trimethylated chitosan chloride (TMC) improves the intestinal permeation of the peptide drug buserelin in vitro (Caco-2 cells) and in vivo (rats).
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pubmed:affiliation |
Division of Pharmaceutical Technology, Leiden/Amsterdam Center for Drug Research, Leiden University, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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