|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
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|
pubmed:dateCreated |
2000-5-15
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|
pubmed:abstractText |
4-Aza-2,3-dehydro-4-deoxypodophyllotoxin analogues 3a-n were synthesized through quinolines 2a-n. Comparison of their cytotoxicity against P-388 leukemia cells revealed that the steric effects of the ring B substituents on the activity are greater than the electronic effects, while the presence of a methoxy group on the ring E is not essential to exhibit potent cytotoxicity. Analogues 3a and 3b proved to be more than twice as cytotoxic as natural podophyllotoxin (1).
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Feb
|
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pubmed:issn |
0960-894X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
21
|
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pubmed:volume |
10
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
315-7
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10714489-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:10714489-Cytotoxins,
pubmed-meshheading:10714489-Inhibitory Concentration 50,
pubmed-meshheading:10714489-Keratolytic Agents,
pubmed-meshheading:10714489-Models, Molecular,
pubmed-meshheading:10714489-Podophyllotoxin,
pubmed-meshheading:10714489-Quinolines,
pubmed-meshheading:10714489-Quinolones,
pubmed-meshheading:10714489-Stereoisomerism,
pubmed-meshheading:10714489-Structure-Activity Relationship,
pubmed-meshheading:10714489-Tumor Cells, Cultured
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|
pubmed:year |
2000
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|
pubmed:articleTitle |
4-Aza-2,3-dehydro-4-deoxypodophyllotoxins: simple aza-podophyllotoxin analogues possessing potent cytotoxicity.
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|
pubmed:affiliation |
Tokyo University of Pharmacy and Life Science, Hachioji, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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