Source:http://linkedlifedata.com/resource/pubmed/id/10713368
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2000-5-25
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pubmed:abstractText |
We analysed longitudinally the numbers of CD3-CD16+ (natural killer cells, NK) and CD3-CD57+ cells (a subset of NK) in 15 IFNbeta1b- and 12 IFNbeta1a-treated relapsing-remitting multiple sclerosis (RRMS) patients. IFNbeta1b (Betaferon)-treated RRMS patients showed a rapid and marked reduction in the number of both NK subsets which started 1 month after therapy initiation, and reached highest significance after 3 months (P=0.000); however, figures reverted to pre-treatment values following the appearance of anti-IFNbeta antibodies. In IFNbeta1a (Avonex)-treated RRMS patients, the decrease in both CD3-CD16+ and CD3-CD57+ cell number was slower but more persistent; anti-IFNbeta antibodies were only rarely detected in these patients, and at lower titers than in IFNbeta1b-treated ones. Our findings suggest that NK cells might be one of the major immunological targets of IFNbeta-based treatments.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0165-5728
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
91-5
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:10713368-Adult,
pubmed-meshheading:10713368-Antibodies,
pubmed-meshheading:10713368-Female,
pubmed-meshheading:10713368-Humans,
pubmed-meshheading:10713368-Interferon-beta,
pubmed-meshheading:10713368-Killer Cells, Natural,
pubmed-meshheading:10713368-Male,
pubmed-meshheading:10713368-Middle Aged,
pubmed-meshheading:10713368-Multiple Sclerosis,
pubmed-meshheading:10713368-Recurrence
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pubmed:year |
2000
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pubmed:articleTitle |
Effect of IFNbeta and anti-IFNbeta antibodies on NK cells in multiple sclerosis patients.
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pubmed:affiliation |
Department of Neurological and Psychiatrical Sciences, Second Neurological Clinic, University of Padova, via E. Vendramini 7, 35137, Padova, Italy.
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pubmed:publicationType |
Journal Article
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