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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-6-21
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pubmed:abstractText |
The observations that Src(-/-) mice develop osteopetrosis and Src family tyrosine kinase inhibitors decrease osteoclast-mediated resorption of bone have implicated Src in the regulation of osteoclast-resorptive activity. We have designed and synthesized a compound, AP22161, that binds selectively to the Src SH2 domain and demonstrated that it inhibits Src-dependent cellular activity and inhibits osteoclast-mediated resorption.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1074-5521
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
225-35
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10712930-Amino Acid Sequence,
pubmed-meshheading:10712930-Animals,
pubmed-meshheading:10712930-Benzoic Acids,
pubmed-meshheading:10712930-Binding Sites,
pubmed-meshheading:10712930-Bone Resorption,
pubmed-meshheading:10712930-Cells, Cultured,
pubmed-meshheading:10712930-Enzyme Inhibitors,
pubmed-meshheading:10712930-Humans,
pubmed-meshheading:10712930-Ligands,
pubmed-meshheading:10712930-Mice,
pubmed-meshheading:10712930-Molecular Sequence Data,
pubmed-meshheading:10712930-Osteoclasts,
pubmed-meshheading:10712930-Rabbits,
pubmed-meshheading:10712930-Rats,
pubmed-meshheading:10712930-Sequence Homology, Amino Acid,
pubmed-meshheading:10712930-Transformation, Genetic,
pubmed-meshheading:10712930-Two-Hybrid System Techniques,
pubmed-meshheading:10712930-src Homology Domains,
pubmed-meshheading:10712930-src-Family Kinases
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pubmed:year |
2000
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pubmed:articleTitle |
A Src SH2 selective binding compound inhibits osteoclast-mediated resorption.
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pubmed:affiliation |
ARIAD Pharmaceuticals Inc., Biogen, Cambridge, Cambridge, MA 02139, USA. shelia_violette@biogen.com
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pubmed:publicationType |
Journal Article,
In Vitro
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