Linked Life Data

10712903

Source:http://linkedlifedata.com/resource/pubmed/id/10712903

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2000-4-11
pubmed:abstractText
Platelet-derived growth factor (PDGF) promotes cell-cycle progression by engaging signaling enzymes such as phospholipase Cgamma (PLCgamma). When activated, PLCgamma cleaves phosphatidylinositol-4,5-bisphosphate to produce inositol-1,4, 5-trisphosphate (IP(3)) and diacylglycerol (DAG). IP(3) stimulates the release of calcium from intracellular stores, which together with DAG activate some protein kinase C (PKC) family members. In this study we focused on putative downstream effectors of PLCgamma - PKC family members. We investigated whether, and when, DAG-responsive PKCs contribute to PDGF-dependent DNA synthesis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0960-9822
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
261-7
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:10712903-Blotting, Western, pubmed-meshheading:10712903-Diglycerides, pubmed-meshheading:10712903-Enzyme Activation, pubmed-meshheading:10712903-G0 Phase, pubmed-meshheading:10712903-Humans, pubmed-meshheading:10712903-Isoenzymes, pubmed-meshheading:10712903-Lipid Metabolism, pubmed-meshheading:10712903-Nucleic Acid Synthesis Inhibitors, pubmed-meshheading:10712903-Phosphatidylinositol 3-Kinases, pubmed-meshheading:10712903-Platelet-Derived Growth Factor, pubmed-meshheading:10712903-Precipitin Tests, pubmed-meshheading:10712903-Protein Kinase C, pubmed-meshheading:10712903-Protein Kinase C-epsilon, pubmed-meshheading:10712903-Receptors, Platelet-Derived Growth Factor, pubmed-meshheading:10712903-S Phase, pubmed-meshheading:10712903-Signal Transduction, pubmed-meshheading:10712903-Time Factors, pubmed-meshheading:10712903-Tumor Cells, Cultured
pubmed:year
2000
pubmed:articleTitle
PDGF initiates two distinct phases of protein kinase C activity that make unequal contributions to the G0 to S transition.
pubmed:affiliation
Schepens Eye Research Institute, Harvard Medical School, Institute of Biotechnology, Boston, MA 02114, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.