rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-3-15
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pubmed:abstractText |
Intravitreal injection of brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), or basic fibroblast growth factor (FGF2) promotes survival of photoreceptors exposed to various types of insults, but it is not known if these survival-promoting effects occur by direct action of the factors on photoreceptors or indirectly through the activation of other cells. In this study, the authors have sought to address this issue by determining which cells in the retina show evidence of activated intracellular signaling pathways acutely and at longer time points after intravitreal injection of these agents.
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pubmed:grant |
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Mar
|
pubmed:issn |
0146-0404
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
927-36
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10711715-Animals,
pubmed-meshheading:10711715-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:10711715-Ciliary Neurotrophic Factor,
pubmed-meshheading:10711715-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:10711715-Fibroblast Growth Factor 2,
pubmed-meshheading:10711715-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:10711715-Glial Fibrillary Acidic Protein,
pubmed-meshheading:10711715-Injections,
pubmed-meshheading:10711715-Mice,
pubmed-meshheading:10711715-Mice, Inbred C57BL,
pubmed-meshheading:10711715-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10711715-Neuroglia,
pubmed-meshheading:10711715-Organ Culture Techniques,
pubmed-meshheading:10711715-Photoreceptor Cells, Vertebrate,
pubmed-meshheading:10711715-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:10711715-Retinal Ganglion Cells,
pubmed-meshheading:10711715-Signal Transduction,
pubmed-meshheading:10711715-Vitreous Body
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pubmed:year |
2000
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pubmed:articleTitle |
Neurotrophic factors cause activation of intracellular signaling pathways in Müller cells and other cells of the inner retina, but not photoreceptors.
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pubmed:affiliation |
Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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