Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-3-15
pubmed:abstractText
Intravitreal injection of brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), or basic fibroblast growth factor (FGF2) promotes survival of photoreceptors exposed to various types of insults, but it is not known if these survival-promoting effects occur by direct action of the factors on photoreceptors or indirectly through the activation of other cells. In this study, the authors have sought to address this issue by determining which cells in the retina show evidence of activated intracellular signaling pathways acutely and at longer time points after intravitreal injection of these agents.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0146-0404
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
927-36
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:10711715-Animals, pubmed-meshheading:10711715-Brain-Derived Neurotrophic Factor, pubmed-meshheading:10711715-Ciliary Neurotrophic Factor, pubmed-meshheading:10711715-Cyclic AMP Response Element-Binding Protein, pubmed-meshheading:10711715-Fibroblast Growth Factor 2, pubmed-meshheading:10711715-Fluorescent Antibody Technique, Indirect, pubmed-meshheading:10711715-Glial Fibrillary Acidic Protein, pubmed-meshheading:10711715-Injections, pubmed-meshheading:10711715-Mice, pubmed-meshheading:10711715-Mice, Inbred C57BL, pubmed-meshheading:10711715-Mitogen-Activated Protein Kinases, pubmed-meshheading:10711715-Neuroglia, pubmed-meshheading:10711715-Organ Culture Techniques, pubmed-meshheading:10711715-Photoreceptor Cells, Vertebrate, pubmed-meshheading:10711715-Proto-Oncogene Proteins c-fos, pubmed-meshheading:10711715-Retinal Ganglion Cells, pubmed-meshheading:10711715-Signal Transduction, pubmed-meshheading:10711715-Vitreous Body
pubmed:year
2000
pubmed:articleTitle
Neurotrophic factors cause activation of intracellular signaling pathways in Müller cells and other cells of the inner retina, but not photoreceptors.
pubmed:affiliation
Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't