Linked Life Data

10711403

Source:http://linkedlifedata.com/resource/pubmed/id/10711403

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2000-3-29
pubmed:abstractText
The U.S. EPA's Reference Dose (RfD) for methylmercury (MeHg) uses a simple one-compartment toxicokinetic model to estimate ingestion doses in mg/kg-day from measured concentrations of mercury in hair. The model includes a number of input variables for which point estimates are made. Uncertainty in the inputs is addressed by the use of a 3-fold uncertainty factor. There are, however, published ranges for each variable which are used to develop distributions for each of the inputs. Monte Carlo output of the model is generated. The 90% confidence interval spans a 3-fold to 5-fold range of ingestion doses for any given concentration of mercury in hair. The hair:blood mercury concentration ratio contributes most to the variance of the output. The results indicate that the uncertainty factor of three is appropriate.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0148-0545
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
293-306
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Uncertainty analysis of the estimated ingestion rates used to derive the methylmercury reference dose.
pubmed:affiliation
National Center for Environmental Assessment, U.S. Environmental Protection Agency, Cincinnati, OH 45268, USA.
pubmed:publicationType
Journal Article