Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-4-12
pubmed:abstractText
The function of the bladder urothelium in modulating contractile responses of the underlying detrusor smooth muscle to muscarinic stimulation has been examined in the pig bladder. Saturation curves for [3H]-QNB binding demonstrated a greater muscarinic receptor density in the urothelium than in the detrusor smooth muscle. The presence of an intact urothelium on isolated bladder strips inhibited contractions induced by carbachol but not KCl. Contractions of a urothelium-denuded muscle strip were inhibited in the presence of a second bladder strip with an intact urothelium, but not if the second strip was denuded. The urothelium-induced inhibition of contractions was not prevented in the presence of L-NOARG, methylene blue, indomethacin, propranolol, suramin, TEA or apamin. The data suggest the presence of a diffusable, urothelium-derived inhibitory factor, which could not be identified but appears to be neither nitric oxide, a cyclo-oxygenase product, a catecholamine, adenosine, GABA nor an EDHF sensitive to apamin.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10711338-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/10711338-1516635, http://linkedlifedata.com/resource/pubmed/commentcorrection/10711338-2443636, http://linkedlifedata.com/resource/pubmed/commentcorrection/10711338-3659114, http://linkedlifedata.com/resource/pubmed/commentcorrection/10711338-7512948, http://linkedlifedata.com/resource/pubmed/commentcorrection/10711338-7579800, http://linkedlifedata.com/resource/pubmed/commentcorrection/10711338-7582549, http://linkedlifedata.com/resource/pubmed/commentcorrection/10711338-7647988, http://linkedlifedata.com/resource/pubmed/commentcorrection/10711338-7869530, http://linkedlifedata.com/resource/pubmed/commentcorrection/10711338-8101362, http://linkedlifedata.com/resource/pubmed/commentcorrection/10711338-8190120, http://linkedlifedata.com/resource/pubmed/commentcorrection/10711338-8264570, http://linkedlifedata.com/resource/pubmed/commentcorrection/10711338-9605564, http://linkedlifedata.com/resource/pubmed/commentcorrection/10711338-9834033, http://linkedlifedata.com/resource/pubmed/commentcorrection/10711338-9915476
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
129
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
416-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Urothelium-derived inhibitory factor(s) influences on detrusor muscle contractility in vitro.
pubmed:affiliation
Department of Biomedical Science, University of Sheffield.
pubmed:publicationType
Journal Article, In Vitro