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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-4-25
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pubmed:abstractText |
Many viruses have evolved mechanisms to evade detection by the host immune system. The herpes simplex gene ICP47 encodes a protein that binds to the host antigen-processing transporter, inhibiting the formation of major histocompatibility complex class I (MHC-I) antigens in infected cells. MHC-I antigen expression is also important in acute allograft rejection. This study was designed to quantitate the effect of adenoviral-mediated gene transfer of ICP47 on MHC-I cell surface expression of human vascular cells. We hypothesized that the transduction of vascular cells with a replication-incompetent adenoviral vector that was expressing ICP47 (AdICP47) would inhibit constitutive and inducible MHC-I expression and thereby reduce the rate of cytolysis of ICP47-transduced vascular cells by sensitized cytotoxic T lymphocytes (CTL).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0741-5214
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
558-66
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10709070-Adenoviridae,
pubmed-meshheading:10709070-Cell Line,
pubmed-meshheading:10709070-Endothelium, Vascular,
pubmed-meshheading:10709070-Fibroblasts,
pubmed-meshheading:10709070-Gene Transfer Techniques,
pubmed-meshheading:10709070-Genetic Vectors,
pubmed-meshheading:10709070-Graft Rejection,
pubmed-meshheading:10709070-Histocompatibility Antigens Class I,
pubmed-meshheading:10709070-Humans,
pubmed-meshheading:10709070-Immediate-Early Proteins,
pubmed-meshheading:10709070-Muscle, Smooth, Vascular,
pubmed-meshheading:10709070-Simplexvirus,
pubmed-meshheading:10709070-Skin,
pubmed-meshheading:10709070-Transduction, Genetic,
pubmed-meshheading:10709070-Viral Proteins
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pubmed:year |
2000
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pubmed:articleTitle |
Adenoviral-mediated gene transfer of ICP47 inhibits major histocompatibility complex class I expression on vascular cells in vitro.
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pubmed:affiliation |
University of California, San Francisco, CA 94143-0222, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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