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rdf:type |
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lifeskim:mentions |
umls-concept:C0007608,
umls-concept:C0021079,
umls-concept:C0021080,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0024264,
umls-concept:C0039194,
umls-concept:C0225336,
umls-concept:C0936012,
umls-concept:C1515895,
umls-concept:C1533691
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pubmed:issue |
4
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pubmed:dateCreated |
2000-3-23
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pubmed:abstractText |
Cyclosporine A (CsA) and tacrolimus prevent proliferation but not transendothelial migration of alloreactive lymphocytes into donor organs. As a result, serious adverse effects, such as nephrotoxicity and neurotoxicity, have been observed under CsA/tacrolimus therapy. The incorporation of new drugs with infiltration blocking properties might enhance the efficacy of the current immunosuppressive protocol, allowing lower CsA/tacrolimus dosage. Because Ca2+ plays a critical role in cell-cell interaction, the Ca2+-channel blocker verapamil might be a good cany. didate for supporting CsA/tacrolimus-based therapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0041-1337
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pubmed:author |
pubmed-author:BachmannMM,
pubmed-author:Bereiter-HahnJJ,
pubmed-author:BlahetaR ARA,
pubmed-author:BrudaJJ,
pubmed-author:CinatlJJ,
pubmed-author:EnckeAA,
pubmed-author:HailerN PNP,
pubmed-author:HarderSS,
pubmed-author:LeckerMM,
pubmed-author:MariniGG,
pubmed-author:OppermannEE,
pubmed-author:ScholzMM,
pubmed-author:WeberSS,
pubmed-author:WittigBB
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
588-97
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10708116-Antigens, CD15,
pubmed-meshheading:10708116-Cell Movement,
pubmed-meshheading:10708116-Dinoprostone,
pubmed-meshheading:10708116-E-Selectin,
pubmed-meshheading:10708116-Endothelium, Vascular,
pubmed-meshheading:10708116-Humans,
pubmed-meshheading:10708116-Immune Tolerance,
pubmed-meshheading:10708116-Intercellular Adhesion Molecule-1,
pubmed-meshheading:10708116-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:10708116-P-Selectin,
pubmed-meshheading:10708116-Protein Binding,
pubmed-meshheading:10708116-T-Lymphocytes,
pubmed-meshheading:10708116-Vascular Cell Adhesion Molecule-1,
pubmed-meshheading:10708116-Verapamil
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pubmed:year |
2000
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pubmed:articleTitle |
In vitro analysis of verapamil-induced immunosuppression: potent inhibition of T cell motility and lymphocytic transmigration through allogeneic endothelial cells.
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pubmed:affiliation |
Department of General Surgery, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany. Blaheta@em.uni-frankfurt.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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