Linked Life Data

10707342

Source:http://linkedlifedata.com/resource/pubmed/id/10707342

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-3-24
pubmed:abstractText
The biological roles of selenium and its mode of action have only recently begun to be revealed. To date, the major functions of selenium can be attributed to its antioxidative properties and its role in the regulation of thyroid hormone metabolism, cell growth and eicosanoid biosynthesis. The unusual feature of selenoprotein synthesis is that selenocysteine insertion is specified by the stop UGA codon. A number of selenocysteine-specific gene products and a stem-loop structure in the 3' untranslated region are required for selenocysteine biosynthesis and the decoding of UGA codons in the open reading frame of the mRNA. The major biological functions of selenium are achieved through its redox activity when present as selenocysteine at the active sites of selenoproteins and these proteins are selenium-dependent since replacement with the sulphur analogue cysteine causes loss of enzyme activity. Both organic and inorganic forms of selenium may be utilised by the body, with the selenoamino acids showing greatest bioavailability. Knowledge of the biochemistry of the element coupled with appropriate techniques for the study of the distribution of selenium species in health and disease could help to identify sensitive markers of selenium status.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0946-672X
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
193-214
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Recent developments in selenium metabolism and chemical speciation: a review.
pubmed:affiliation
Division of Chemistry, Sheffield Hallam University, Howard St., Sheffield, U.K.
pubmed:publicationType
Journal Article, Review