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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-5-9
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pubmed:abstractText |
A dynamic positive feedback mechanism, known as 'facilitation', augments L-type calcium-ion currents (ICa) in response to increased intracellular Ca2+ concentrations. The Ca2+-binding protein calmodulin (CaM) has been implicated in facilitation, but the single-channel signature and the signalling events underlying Ca2+/CaM-dependent facilitation are unknown. Here we show that the Ca2+/CaM-dependent protein kinase II (CaMK) is necessary and possibly sufficient for ICa facilitation. CaMK induces a channel-gating mode that is characterized by frequent, long openings of L-type Ca2+ channels. We conclude that CaMK-mediated phosphorylation is an essential signalling event in triggering Ca2+/CaM-dependent ICa facilitation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1465-7392
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
173-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10707089-Animals,
pubmed-meshheading:10707089-Barium,
pubmed-meshheading:10707089-Calcium,
pubmed-meshheading:10707089-Calcium Channels, L-Type,
pubmed-meshheading:10707089-Calcium-Calmodulin-Dependent Protein Kinase Type 2,
pubmed-meshheading:10707089-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:10707089-Calmodulin,
pubmed-meshheading:10707089-Cell Membrane,
pubmed-meshheading:10707089-Cells, Cultured,
pubmed-meshheading:10707089-Enzyme Activation,
pubmed-meshheading:10707089-Enzyme Inhibitors,
pubmed-meshheading:10707089-Feedback,
pubmed-meshheading:10707089-Ion Channel Gating,
pubmed-meshheading:10707089-Mice,
pubmed-meshheading:10707089-Myocardium,
pubmed-meshheading:10707089-Patch-Clamp Techniques,
pubmed-meshheading:10707089-Peptides,
pubmed-meshheading:10707089-Phosphorylation,
pubmed-meshheading:10707089-Signal Transduction
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pubmed:year |
2000
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pubmed:articleTitle |
Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels.
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pubmed:affiliation |
Department of Anesthesiology, Vanderbilt University, Nashville, Tennessee 37232, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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