Source:http://linkedlifedata.com/resource/pubmed/id/10706720
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2000-3-28
|
| pubmed:abstractText |
Current vaccines designed to promote humoral immunity to respiratory virus infections also induce potent CD4+ T cell memory. However, little is known about the impact of primed CD4+ T cells on the immune response to heterologous viruses that are serologically distinct, but that share CD4+ T cell epitopes. In addition, the protective capacity of primed CD4+ T cells has not been fully evaluated. In the present study, we addressed these two issues using a murine Sendai virus model. Mice were primed with an HN421-436 peptide that represents the dominant CD4+ T cell epitope on the hemagglutinin-neuraminidase (HN) of Sendai virus. This vaccination strategy induced strong CD4+ T cell memory to the peptide, but did not induce Abs specific for the Sendai virus virion. Subsequent Sendai virus infection of primed mice resulted in 1) a substantially accelerated virus-specific CD4+ T cell response in the pneumonic lung; 2) enhanced primary antiviral Ab-forming cell response in the mediastinal lymph nodes; and 3) accelerated viral clearance. Interestingly, the virus-specific CD8+ T cell response in the lung and the development of long-term memory CD8+ T cells in the spleen were significantly reduced. Taken together, our data demonstrate that primed CD4+ T cells, in the absence of pre-existing Ab, can have a significant effect on the subsequent immune responses to a respiratory virus infection.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/HN Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
164
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3274-82
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:10706720-Adjuvants, Immunologic,
pubmed-meshheading:10706720-Animals,
pubmed-meshheading:10706720-Antibodies, Viral,
pubmed-meshheading:10706720-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10706720-CD8-Positive T-Lymphocytes,
pubmed-meshheading:10706720-Cell Movement,
pubmed-meshheading:10706720-Cytotoxicity, Immunologic,
pubmed-meshheading:10706720-Epitopes, T-Lymphocyte,
pubmed-meshheading:10706720-Female,
pubmed-meshheading:10706720-HN Protein,
pubmed-meshheading:10706720-Immunologic Memory,
pubmed-meshheading:10706720-Leukocytosis,
pubmed-meshheading:10706720-Lung,
pubmed-meshheading:10706720-Lymphoid Tissue,
pubmed-meshheading:10706720-Mice,
pubmed-meshheading:10706720-Mice, Inbred C57BL,
pubmed-meshheading:10706720-Neutrophils,
pubmed-meshheading:10706720-Peptide Fragments,
pubmed-meshheading:10706720-Respirovirus,
pubmed-meshheading:10706720-Respirovirus Infections,
pubmed-meshheading:10706720-T-Lymphocytes, Cytotoxic
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
CD4+ T cell priming accelerates the clearance of Sendai virus in mice, but has a negative effect on CD8+ T cell memory.
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| pubmed:affiliation |
Trudeau Institute, Saranac Lake, NY 12983, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|