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pubmed-article:10705175pubmed:abstractTextChronic use of sennoside laxatives often causes pseudomelanosis coli. A recent study suggested that pseudomelanosis coli is associated with an increased colorectal cancer risk. A single high dose of highly purified senna extract increased proliferation rate and reduced crypt length in the sigmoid colon compared to historical controls.lld:pubmed
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pubmed-article:10705175pubmed:copyrightInfoCopyright 2000 S. Karger AG, Basellld:pubmed
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pubmed-article:10705175pubmed:articleTitleInfluence of a highly purified senna extract on colonic epithelium.lld:pubmed
pubmed-article:10705175pubmed:affiliationDepartment of Gastroenterology and Hepatology, University Hospital, Groningen, The Netherlands.lld:pubmed
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