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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-4-26
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pubmed:abstractText |
Chronic use of sennoside laxatives often causes pseudomelanosis coli. A recent study suggested that pseudomelanosis coli is associated with an increased colorectal cancer risk. A single high dose of highly purified senna extract increased proliferation rate and reduced crypt length in the sigmoid colon compared to historical controls.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0012-2823
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2000 S. Karger AG, Basel
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
113-20
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10705175-Adolescent,
pubmed-meshheading:10705175-Adult,
pubmed-meshheading:10705175-Aged,
pubmed-meshheading:10705175-Apoptosis,
pubmed-meshheading:10705175-Biopsy, Needle,
pubmed-meshheading:10705175-Cathartics,
pubmed-meshheading:10705175-Cell Division,
pubmed-meshheading:10705175-Colon,
pubmed-meshheading:10705175-Colonoscopy,
pubmed-meshheading:10705175-Colorectal Neoplasms,
pubmed-meshheading:10705175-Confidence Intervals,
pubmed-meshheading:10705175-Dose-Response Relationship, Drug,
pubmed-meshheading:10705175-Female,
pubmed-meshheading:10705175-Humans,
pubmed-meshheading:10705175-Male,
pubmed-meshheading:10705175-Middle Aged,
pubmed-meshheading:10705175-Probability,
pubmed-meshheading:10705175-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:10705175-Reference Values,
pubmed-meshheading:10705175-Risk Assessment,
pubmed-meshheading:10705175-Senna Extract,
pubmed-meshheading:10705175-Tumor Suppressor Protein p53
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pubmed:year |
2000
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pubmed:articleTitle |
Influence of a highly purified senna extract on colonic epithelium.
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pubmed:affiliation |
Department of Gastroenterology and Hepatology, University Hospital, Groningen, The Netherlands.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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