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rdf:type |
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lifeskim:mentions |
umls-concept:C0017071,
umls-concept:C0017262,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0042395,
umls-concept:C0079189,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0682002,
umls-concept:C0752177,
umls-concept:C0971125,
umls-concept:C2911684
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pubmed:issue |
1-2
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pubmed:dateCreated |
2000-6-29
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pubmed:abstractText |
Sympathetic ganglia consist of noradrenergic and cholinergic neurons. The cholinergic marker protein vesicular acetylcholine transporter (VAChT) and the neuropeptide vasoactive intestinal peptide (VIP), co-expressed in mature cholinergic sympathetic neurons, are first detectable during embryonic development of rat sympathetic ganglia. However, the subpopulation of cholinergic sympathetic neurons which innervates sweat glands in mammalian footpads starts to express VAChT and VIP during the first postnatal weeks, under the influence of sweat gland-derived signals. In vitro evidence suggests that the sweat gland-derived cholinergic differentiation factor belongs to a group of neuropoietic cytokines, including LIF, CNTF and CT-1, that act through a LIFRbeta-containing cytokine receptor. To investigate whether the embryonic expression of cholinergic properties is elicited by a related cytokine, the expression of VAChT and VIP was analyzed in stellate ganglia of mice deficient for the cytokine receptor subunits LIFRbeta or CNTFRalpha. The density of VAChT- and VIP-immunoreactive cells in stellate ganglia of new-born animals was not different in LIFRbeta(-/-) and CNTFRalpha(-/-) ganglia as compared to ganglia from wild-type mice. These results demonstrate that the early, embryonic expression of VAChT and VIP is not induced by cytokines acting through LIFRbeta- or CNTFRalpha-containing receptors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ciliary Neurotrophic Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Leukemia Inhibitory Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Leukemia Inhibitory Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Lif protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Lifr protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Lifr protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Ciliary Neurotrophic...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, OSM-LIF,
http://linkedlifedata.com/resource/pubmed/chemical/Slc18a3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Slc18a3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoactive Intestinal Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Acetylcholine Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Transport Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0925-4773
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
91-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10704834-Animals,
pubmed-meshheading:10704834-Carrier Proteins,
pubmed-meshheading:10704834-Ciliary Neurotrophic Factor,
pubmed-meshheading:10704834-Growth Inhibitors,
pubmed-meshheading:10704834-Interleukin-6,
pubmed-meshheading:10704834-Leukemia Inhibitory Factor,
pubmed-meshheading:10704834-Leukemia Inhibitory Factor Receptor alpha Subunit,
pubmed-meshheading:10704834-Lymphokines,
pubmed-meshheading:10704834-Membrane Transport Proteins,
pubmed-meshheading:10704834-Mice,
pubmed-meshheading:10704834-Rabbits,
pubmed-meshheading:10704834-Rats,
pubmed-meshheading:10704834-Receptor, Ciliary Neurotrophic Factor,
pubmed-meshheading:10704834-Receptors, Cytokine,
pubmed-meshheading:10704834-Receptors, OSM-LIF,
pubmed-meshheading:10704834-Stellate Ganglion,
pubmed-meshheading:10704834-Vasoactive Intestinal Peptide,
pubmed-meshheading:10704834-Vesicular Acetylcholine Transport Proteins,
pubmed-meshheading:10704834-Vesicular Transport Proteins
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pubmed:year |
2000
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pubmed:articleTitle |
The early expression of VAChT and VIP in mouse sympathetic ganglia is not induced by cytokines acting through LIFRbeta or CNTFRalpha.
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pubmed:affiliation |
Max-Planck-Institut für Hirnforschung, Abt. Neurochemie, Deutschordenstrasse 46, 60528, Frankfurt am Main, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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