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rdf:type |
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lifeskim:mentions |
umls-concept:C0014116,
umls-concept:C0020740,
umls-concept:C0086296,
umls-concept:C0599956,
umls-concept:C1100734,
umls-concept:C1335823,
umls-concept:C1522408,
umls-concept:C1697272,
umls-concept:C1704608,
umls-concept:C1704675,
umls-concept:C1704806,
umls-concept:C1705135,
umls-concept:C1825023,
umls-concept:C2931019
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pubmed:issue |
1-2
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pubmed:dateCreated |
2000-4-24
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pubmed:abstractText |
During the development of a coated ibuprofen formulation a sticking tendency occurred when applying Aquacoat ECD. This interaction indicated the formation of a eutectic mixture. The compatibility of the components of Aquacoat ECD with ibuprofen was investigated by differential scanning calorimetry. Cetyl alcohol, a stabilizing excipient in Aquacoat, was found to form a eutectic system with ibuprofen. It was characterized by the construction of a phase diagram with 33 mol% ibuprofen and an onset temperature of 40.5 degrees C. Wide-angle X-ray diffraction was used to identify the polymorphic forms of cetyl alcohol. The results confirmed the amorphous state in the aqueous dispersion in contrast to the beta(0)- and gamma(4)-polymorphs of solid cetyl alcohol.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0378-5173
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
197
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
35-9
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pubmed:dateRevised |
2000-12-18
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pubmed:meshHeading |
pubmed-meshheading:10704791-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:10704791-Calorimetry, Differential Scanning,
pubmed-meshheading:10704791-Cellulose,
pubmed-meshheading:10704791-Excipients,
pubmed-meshheading:10704791-Fatty Alcohols,
pubmed-meshheading:10704791-Ibuprofen,
pubmed-meshheading:10704791-Surface Properties,
pubmed-meshheading:10704791-Thermodynamics,
pubmed-meshheading:10704791-X-Ray Diffraction
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pubmed:year |
2000
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pubmed:articleTitle |
Interactions during aqueous film coating of ibuprofen with aquacoat ECD.
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pubmed:affiliation |
Department of Pharmaceutical Technology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, Germany.
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pubmed:publicationType |
Journal Article
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