Source:http://linkedlifedata.com/resource/pubmed/id/10704684
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2000-3-17
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| pubmed:abstractText |
We analyzed the loss of heterozygosity (LOH) for 1p in 18 Wilms tumors using a panel of 11 polymorphic markers. Loss of heterozygosity was identified in 56% of the tumors. The smallest region of overlap was defined for marker D1S247, underlying the 1p35-1p36.1 locus. This is the highest LOH frequency for 1p, or for the well-defined 11p13 and 11p15.5 loci. Based on the fact that tumors of all stages, with both favorable and unfavorable histology, exhibited LOH, we suggest that the 1p35-1p36.1 locus is involved in the etiology of Wilms tumor.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0165-4608
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
117
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
136-9
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| pubmed:dateRevised |
2005-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10704684-Child,
pubmed-meshheading:10704684-Child, Preschool,
pubmed-meshheading:10704684-Chromosomes, Human, Pair 1,
pubmed-meshheading:10704684-Humans,
pubmed-meshheading:10704684-Infant,
pubmed-meshheading:10704684-Kidney Neoplasms,
pubmed-meshheading:10704684-Loss of Heterozygosity,
pubmed-meshheading:10704684-Microsatellite Repeats,
pubmed-meshheading:10704684-Neoplasm Staging,
pubmed-meshheading:10704684-Wilms Tumor
|
| pubmed:year |
2000
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| pubmed:articleTitle |
High frequency of loss of heterozygosity for 1p35-p36 (D1S247) in Wilms tumor.
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| pubmed:affiliation |
Department of Pediatric Surgery, Tel Aviv, Israel.
|
| pubmed:publicationType |
Journal Article
|