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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-4-28
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pubmed:abstractText |
Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Latin America. Patients with PCM show a wide spectrum of clinical and pathological manifestations depending on both host and pathogen factors. Two clinical forms of the disease are recognized: the acute or juvenile form and the chronic or adult form. The major antigenic component of the parasite is a glycoprotein of 43 kDa (gp43). All patient sera present antibodies against gp43 (anti-gp43) and, as demonstrated before by our group, spontaneous anti-idiotypic (anti-Id) antibodies (Ab2) can be detected in patient sera with high titers of anti-gp43. Since it has been postulated that anti-Id antibodies may have a modulating function, we decided to purify and characterize anti-Id antibodies in this system. The possible correlation of Ab2 titers with different clinical forms of disease was also verified. Results showed that purified human anti-Id antibodies (human Ab2) recognized specifically the idiotype of some murine monoclonal anti-gp43 (17c and 3e) but not others (40.d7, 27a, and 8a). Spontaneous anti-Id antibodies were found in all clinical forms of disease. The majority of patients (88%, n = 8) with the acute form of PCM had high titers of Ab2. However, among patients with the multifocal chronic form of the disease, only 29% (n = 14) had high titers of Ab2; 70% (n = 10) of patients with the unifocal chronic form had low titers of Ab2. A correlation between Ab2 titers and anti-gp43 titers was observed before and during antimycotic treatment. Our results suggest that titers of anti-Id antibodies correlate with the severity of PCM in humans.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702489-1281819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702489-13699155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702489-1585444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10702489-1722220,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10702489-9764601
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/43 kDa protein, Paracoccidioides,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Anti-Idiotypic,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Fungal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antifungal Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Fungal,
http://linkedlifedata.com/resource/pubmed/chemical/Fluconazole,
http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Itraconazole,
http://linkedlifedata.com/resource/pubmed/chemical/Oligosaccharides
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1071-412X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
175-81
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10702489-Adult,
pubmed-meshheading:10702489-Animals,
pubmed-meshheading:10702489-Antibodies, Anti-Idiotypic,
pubmed-meshheading:10702489-Antibodies, Fungal,
pubmed-meshheading:10702489-Antibodies, Monoclonal,
pubmed-meshheading:10702489-Antifungal Agents,
pubmed-meshheading:10702489-Antigens, Fungal,
pubmed-meshheading:10702489-Fluconazole,
pubmed-meshheading:10702489-Follow-Up Studies,
pubmed-meshheading:10702489-Fungal Proteins,
pubmed-meshheading:10702489-Glycoproteins,
pubmed-meshheading:10702489-Humans,
pubmed-meshheading:10702489-Itraconazole,
pubmed-meshheading:10702489-Mice,
pubmed-meshheading:10702489-Oligosaccharides,
pubmed-meshheading:10702489-Paracoccidioides,
pubmed-meshheading:10702489-Paracoccidioidomycosis
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pubmed:year |
2000
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pubmed:articleTitle |
Anti-idiotypic antibodies in patients with different clinical forms of paracoccidioidomycosis.
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pubmed:affiliation |
Discipline of Immunology, Federal University of São Paulo (UNIFESP), São Paulo Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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