Linked Life Data

10701765

Source:http://linkedlifedata.com/resource/pubmed/id/10701765

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2000-3-23
pubmed:abstractText
Certain high lean gain swine genotypes have greater sensitivity to pathogen and nonpathogen stressors evident by reduced productivity and increased mortality during disease stress or in suboptimal production environments. Saline (control) and an immunologic challenge (LPS; 25 microg lipopolysaccharide/kg BW) were administered to three genetic populations (each pig used as its own control): high lean (H), moderate lean terminal cross (MT), and moderate lean maternal cross (MM). LPS induced anorexia, and significantly increased body temperature and circulating TNF-alpha, cortisol, and NEFA in all genotypes (P < 0.0004). LPS reduced circulating glucose, insulin, and IGF-1 in all genotypes (P < 0.05). The LPS-induced hypoglycemia was significantly greater in MM versus MT and H pigs (P < 0.03). The hypoinsulinemia was significantly greater in MM versus H pigs (P < 0.02). MM pigs recovered from hypoinsulinemia slower than MT pigs (P < 0.03). Control insulin was higher in H versus MT pigs (P < 0.08), but relative to basal, the insulin response to LPS was similar. Plasma haptoglobin response to LPS was lower for MM versus MT and H pigs (P < 0.02), and tended to be lower in MT versus H pigs (P < 0.09). LPS treatment caused similar decreases in plasma IGF-1 concentrations among genotypes. Ten hours after LPS treatment, leptin mRNA abundance in adipose tissue was significantly reduced (relative to control) in MM and H pigs (P < 0.02) but not in MT pigs (P > 0.05). Physiological differences in leptin, a potent regulator of food intake and energy metabolism, may be important factors in the genetic variation in sensitivity to environmental stress.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0739-7240
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-82
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:10701765-Adipose Tissue, pubmed-meshheading:10701765-Animals, pubmed-meshheading:10701765-Blood Glucose, pubmed-meshheading:10701765-Colorimetry, pubmed-meshheading:10701765-Crosses, Genetic, pubmed-meshheading:10701765-Electrophoresis, Polyacrylamide Gel, pubmed-meshheading:10701765-Endotoxemia, pubmed-meshheading:10701765-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:10701765-Escherichia coli Infections, pubmed-meshheading:10701765-Fatty Acids, Nonesterified, pubmed-meshheading:10701765-Genotype, pubmed-meshheading:10701765-Hydrocortisone, pubmed-meshheading:10701765-Image Processing, Computer-Assisted, pubmed-meshheading:10701765-Insulin, pubmed-meshheading:10701765-Insulin-Like Growth Factor I, pubmed-meshheading:10701765-Leptin, pubmed-meshheading:10701765-Male, pubmed-meshheading:10701765-Nucleic Acid Hybridization, pubmed-meshheading:10701765-RNA, pubmed-meshheading:10701765-Radioimmunoassay, pubmed-meshheading:10701765-Swine, pubmed-meshheading:10701765-Swine Diseases, pubmed-meshheading:10701765-Tumor Necrosis Factor-alpha
pubmed:year
2000
pubmed:articleTitle
Physiological response to acute endotoxemia in swine: effect of genotype on energy metabolites and leptin.
pubmed:affiliation
Department of Animal Sciences, Purdue University, West Lafayette, IN, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't