Source:http://linkedlifedata.com/resource/pubmed/id/10700185
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2000-4-7
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| pubmed:abstractText |
The genes Tlx1 (Hox11), Enx (Hox11L2, Tlx-2) and Rnx (Hox11L2, Tlx-3) constitute a family of orphan homeobox genes. In situ hybridization has revealed considerable overlap in their expression within the nervous system, but Rnx is singularly expressed in the developing dorsal and ventral region of the medulla oblongata. Tlx1-deficient and Enx-deficient mice display phenotypes in tissues where the mutated gene is singularly expressed, resulting in asplenogenesis and hyperganglionic megacolon, respectively. To determine the developmental role of Rnx, we disrupted the locus in mouse embryonic stem (ES) cells. Rnx deficient mice developed to term, but all died within 24 hours after birth from a central respiratory failure. The electromyographic activity of intercostal muscles coupled with the C4 ventral root activity assessed in a medulla-spinal cord preparation revealed a high respiratory rate with short inspiratory duration and frequent apnea. Furthermore, a coordinate pattern existed between the abnormal activity of inspiratory neurons in the ventrolateral medulla and C4 motorneuron output, indicating a central respiratory defect in Rnx mice. Thus, Rnx is critical for the development of the ventral medullary respiratory centre and its deficiency results in a syndrome resembling congenital central hypoventilation.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tlx1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/polycomb group proteins
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
|
| pubmed:issn |
1061-4036
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
24
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
287-90
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10700185-Abnormalities, Multiple,
pubmed-meshheading:10700185-Animals,
pubmed-meshheading:10700185-Apnea,
pubmed-meshheading:10700185-Cyanosis,
pubmed-meshheading:10700185-Electromyography,
pubmed-meshheading:10700185-Embryonic and Fetal Development,
pubmed-meshheading:10700185-Genes, Homeobox,
pubmed-meshheading:10700185-Genes, Lethal,
pubmed-meshheading:10700185-Genotype,
pubmed-meshheading:10700185-Gestational Age,
pubmed-meshheading:10700185-Homeodomain Proteins,
pubmed-meshheading:10700185-Hypoventilation,
pubmed-meshheading:10700185-In Situ Hybridization,
pubmed-meshheading:10700185-Intercostal Muscles,
pubmed-meshheading:10700185-Medulla Oblongata,
pubmed-meshheading:10700185-Mice,
pubmed-meshheading:10700185-Mice, Knockout,
pubmed-meshheading:10700185-Motor Neurons,
pubmed-meshheading:10700185-Neurons,
pubmed-meshheading:10700185-Oncogene Proteins,
pubmed-meshheading:10700185-Repressor Proteins,
pubmed-meshheading:10700185-Respiratory Center,
pubmed-meshheading:10700185-Spinal Cord
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| pubmed:year |
2000
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| pubmed:articleTitle |
Rnx deficiency results in congenital central hypoventilation.
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| pubmed:affiliation |
Howard Hughes Medical Institute, Departments of Medicine and Pathology, Washington University School of Medicine, St. Louis, Missouri, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|