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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2000-4-26
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pubmed:abstractText |
Major histocompatibility complex (MHC) class II molecules bind and present to CD4(+) T cells peptides derived from endocytosed antigens. Class II molecules associate in the endoplasmic reticulum with invariant chain (Ii), which (i) mediates the delivery of the class II-Ii complexes into the endocytic compartments where the antigenic peptides are generated; and (ii) blocks the peptide-binding site of the class II molecules until they reach their destination. Once there, Ii must be removed to allow peptide binding. The bulk of Ii-class II complexes reach late endocytic compartments where Ii is eliminated in a reaction in which the cysteine protease cathepsin S and the accessory molecule H-2DM play an essential role. Here, we here show that Ii is also eliminated in early endosomal compartments without the intervention of cysteine proteases or H-2DM. The Ii-free class II molecules generated by this alternative mechanism first bind high molecular weight polypeptides and then mature into peptide-loaded complexes.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-10072072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-10072073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-10322421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-10562280,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-7481823,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-7642700,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-7807005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-7895165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-8011283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-8013468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-8064228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-8065450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-8276796,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-8612130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-8617217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-8638109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-8689559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-8814253,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-8976171,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-9254653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-9311912,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-9539769,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-9639994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-9657147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10698930-9780175
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
882-91
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10698930-Animals,
pubmed-meshheading:10698930-Antigen Presentation,
pubmed-meshheading:10698930-Biological Transport,
pubmed-meshheading:10698930-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10698930-Cysteine Endopeptidases,
pubmed-meshheading:10698930-Endosomes,
pubmed-meshheading:10698930-H-2 Antigens,
pubmed-meshheading:10698930-Histocompatibility Antigens Class II,
pubmed-meshheading:10698930-Mice,
pubmed-meshheading:10698930-Mice, Inbred C57BL
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pubmed:year |
2000
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pubmed:articleTitle |
Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM.
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pubmed:affiliation |
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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